Intravenous clonidine for suppression of haemodynamic response to laparoscopy- a prospective randomised, placebo controlled, single centre study

Authors

  • Pradnya M. Bhalerao Department of Anaesthesia, Government Medical College, Miraj, Maharashtra, India
  • Shalini K. Thombre Department of Emergency Medicine, Dr. DY Patil Medical College, Hospital and Research Centre; DY Patil Vidyapeeth, Pimpri, Pune, Maharashtra, India
  • Upendra S. Kapse Department of Anaesthesiology, BJ Government Medical College, Pune, Maharashtra, India
  • Kunal V. Targe Anaesthesiologist, NHS, Lincoln, UK

DOI:

https://doi.org/10.18203/2349-3933.ijam20172273

Keywords:

Clonidine, neuroendocrine response, laparoscopy

Abstract

Background: Laparoscopic surgeries, including cholecystectomy are being performed on a large scale owing to the improved tissue healing and minimal hospital stay. However the haemodynamic response to pneumoperitoneum could pose a problem in these patients. The primary objective of this study was to evaluate the effectiveness of 1µg/kg intravenous clonidine in suppression of this hemodynamic response. The secondary objective was to assess the postoperative analgesia and sedation.

Methods: 60 patients posted for laparoscopic cholecystectomy were divided into two groups. 30 patients received intravenous midazolam 0.03mg/kg and pentazocine 0.3mg/kg and the other 30 received intravenous clonidine 1µg/kg 15 minutes prior induction.

Results: Intraoperative mean pulse rate was 90.82±4.81 beats per minute in control group. In clonidine group it was 74.76±9.88 beats per minute (p<0.05 significant). Similarly the mean systolic blood pressure was 137.87±4.89 and 125.79±6.44 respectively (p<0.05-significant). The duration of postoperative analgesia was 334.83±24.65 and 116.05±19.17 minutes respectively (p<0.05).

Conclusions: Premedication with intravenous clonidine, has been found to be relatively safe as well as an effective method that provides stable haemodynamics and protection against stress response induced by pneumoperitoneum in patients undergoing laparoscopic cholecystectomy.

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Author Biography

Pradnya M. Bhalerao, Department of Anaesthesia, Government Medical College, Miraj, Maharashtra, India

Associate professor,Anaesthesiology

References

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Published

2017-05-23

How to Cite

Bhalerao, P. M., Thombre, S. K., Kapse, U. S., & Targe, K. V. (2017). Intravenous clonidine for suppression of haemodynamic response to laparoscopy- a prospective randomised, placebo controlled, single centre study. International Journal of Advances in Medicine, 4(3), 788–792. https://doi.org/10.18203/2349-3933.ijam20172273

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Original Research Articles