Published: 2017-05-23

Correlation of microalbuminuria with glycosylated haemoglobin in patients of diabetes having nephropathy

Mayank Gupta, Jagat Pal Singh


Background: Diabetes mellitus is the leading cause of end stage renal disease (ESRD) and is responsible for 30-40% of all ESRD. Objectives of the study were to assess the renal functional status in diabetic nephropathy patients by evaluating and correlating glycosylated haemoglobin levels in diabetic with microalbuminuria.

Methods: Present observational study was done including 75 patients having diabetic nephropathy, who attended JAH and attached groups of hospitals from May 2014 to November 2015. Detailed medical history including duration of diabetes and relevant clinical examination including glycated haemoglobin, blood urea, serum creatinine, and urinary microalbumin were recorded for each patient. All the analysis was performed using IBM SPSS Ver. 20. Significance is assessed at 5% level of significance.

Results: Mean age of study population was 52.4±15.2 years with male preponderance (58.67%). Increased micturation frequency (48%) was the most common presenting symptoms. Mean fasting blood sugar (FBS), post prandial blood sugar (PPBS), HbA1c, duration of diabetes, blood pressure, microalbuminuria and serum creatinine was 151.5±48.5 mg/dL and 240.3±59.7 mg/dL, 9.03±2.1%, 9.37±5.96 years, 132±22.4/84±12.5 mmHg, 118.6±86.7 mg/day and 1.33±0.64 mg/dl respectively. Microalbuminuria (r=0.91, p≤0.05), HbA1c (r=0.67, p≤0.05) and serum Creatinine (r=0.33, p≤0.05) were positively correlated with duration of diabetes.

Conclusions: Level of microalbuminuria increase with increase in duration of diabetes and worsening of diabetes.


Diabetic nephropathy, End stage kidney disease, HbA1c, Microalbuminuria

Full Text:



Kumar R, Abbas A, Fausto N, Aster JC, eds. Robbins and Cotron “Pathologic basis of disease” 8th Ed. Saunders Elsevier Publishing Division; 2010:934-935, 1131-1146.

Robbins SL, Tucker AW. The cause of death in diabetes: a report of 307 autopsied cases. N Engl Med. 1944;231:865-8.

Daminov BT. The effects of eprosartan mesylate and lercanidipine on reducing microalbuminuria. Int J Bio Med. 2013;3(2):70-3.

Viberti GC, Jarrett RJ, Mahmud U, Hill RD, Argyropoulos A, Keen H. Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus. Lancet. 1982;319(8287):1430-2.

Mogensen CE. Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. N Engl J Med. 1984;310:356-60.

Alamdari MI, Aminisani N, Bashardoost B, Shamshirgaran SM, Khodamoradzadeh M, Shokrabadi M, et al. Prevalence and risk factors of microalbuminuria in type 2 diabetic patients in a diabetic clinic of Ardabil-Iran. Int J Endocrinol Metab. 2006;4:8-12.

Baig JA, Asif N, Sarfaraz A, Alam JM. Correlation of microalbuminuria with glycosylated hemoglobin (Hba1c) and duration of type 2 diabetes mellitus (T2DM) in male and female patients. Middle-East J Sci Res. 2016;24(9):2900-3.

Raman S, Dai H, DeLurgio SA, Williams DD, Lind M, Patton SR, et al. High hemoglobin A1c variability is associated with early risk of microalbuminuria in children with T1D. Pediatr Diabetes. 2016;17(6):398-406.

Penno G, Solini A, Bonora E, Fondelli C, Orsi E, Zerbin G, et al. HbA1c variability as an independent correlate of nephropathy, but not retinopathy, in patients with type 2 diabetes. Diabetes Care. 2013;36:2301-10.

Kumar S, Aneja GK, Trivedi A, Atam V, Shankhwar SN, Panwar A, et al. Correlation of diabetic nephropathy and hba1c in newly diagnosed type 2 diabetic patients of Western UP. Int J Sci Res Publ. 2014;4(12):1-4.

Unuigbe EI, Omeife H, Edema T, Ukoli FA. Microalbuminuria and associated factors in newly diagnosed diabetics. Niger Postgrad Med J. 2001;8(4):187-92.

Liu Z, Fu C, Wang W, Xu B. Prevalence of chronic complications of type 2 diabetes mellitus in outpatients-a cross-sectional hospital based survey in urban China. Health and Quality of Life Outcomes. 2010;8(1):62.

Khan NJ, Farid MI, Hameed S, Aziz M. Frequency of microalbuminuria in newly diagnosed type 2 diabetics at Nishtar Hospital, Multan. Ann King Edward Med Coll. 2004;10(4):374-5.