Trifluoperazine induced blepharospasm: a case report
DOI:
https://doi.org/10.18203/2349-3933.ijam20172289Keywords:
Adverse drug reaction, Blepharospasm, TrifluoperazineAbstract
We hereby report an unusual case of trifluoperazine (typical antipsychotic drug) induced tardive blephrospasm which was relieved subsequently after dechallenging the drug. Thereafter patient was started with clozapine (atypical antipsychotic drug). This possibility of blepharospasm should always be kept in mind while prescribing trifluoperazine.
References
Tendon R, Nasr Allah HA, Keshavan MS. Schizophrenia, “Just the Facts” 5. Treatment and prevention Past, present, and future. Schizophrenia Res. 2010;122(1-3):1-23.
Owens DC. Meet the relatives: a reintroduction to the clinical pharmacology of “typical” antipsychotics. Adv Psychiatr Treatment. 2012;18:337-50.
Sood T, Tomar M, Sharma A, Ravinder G. Trifluoperazine Induced Blepharospasm - A Missed Diagnosis. Ann Clin Case Rep. 2016;1:1092.
Marques LDO, Soares B, de Lima SM. Trifluoperazine for schizophrenia. Cochrane Database Syst Rev. 2004;1:CD003545.
Taylor D, Paton C, Kapur S. Use of psychotropics in special patient groups. In: The Maudsley Prescribing Guidelines 2005-2006. London, UK: Informa Healthcare; 2009:259-335.
Barnes TR, Katona CL. Susceptibility to drug-induced hypotension in post-partum psychosis. Int Clin Psychopharmacol. 1986;1:74-6.
Sachdev P. Tardive blepharospasm. Movement Disorders. 1998;13:947-51.
Marder SR. Management of schizophrenia. J Clin Psych. 1996;57:9-13.
Gerlach J, Lublin H, Peacock L. Extrapyramidal symptoms during long-term treatment with antipsychotics, Special focus on clozapine and D 1 and D 2 dopamine antagonists. Neuropsycho Pharmacol. 1996;14(3):35-9.
Dalek GW, Becks L, Meador WJH. Tardive dyskinesia, clozapine, and treatment response. Prog Neuro Psychopharmacol Biol Psych. 1998;22(4):567-73.