Published: 2017-07-20

Association between hypokalemia and cardiovascular diseases among hospitalized patients in tertiary care teaching hospital in North Karnataka: a retrospective study

Raju H. Badiger, Santosh B. Desai, Ravindra Kantamanenin, Chetana K. Kavatkopp, Joel George, Sheikh H. Basha


Background: Potassium is an extremely crucial element in maintaining the normal charge between intracellular and extracellular space. Normal cellular function is maintained through potassium homeostasis. The normal range of plasma potassium is 3.5 to 5.1 mmol/L. The deviation both hypo and hyperkalaemia are associated with cardiovascular diseases especially cardiac arrhythmia. The objective was to study the association of hypokalaemia on cardiovascular diseases.

Methods: During this one year of retrospective study socio-demographic profile of the patients were collected from the medical record section of hospital. The participants were grouped into four classes based on the serum potassium levels as, Group A: < 2 mmol/L, group B: 2-2.49 mmol/l, group C: 2.5 - 2.9 mmol/L, group D: 3 - 3.49 mmol/L and group E (control group) 3.5 to 5.1 mmol/L. The participants were also grouped as those suffering from cardiovascular diseases and those with non-cardiovascular diseases.

Results: In our study 4818 records were categorized into 5 groups including control group. Males (61.35%) were slightly more than female (38.65%). The mean age group was 43±4 years. Results revealed that there was positive association between the sexes. Females were more commonly associated as compared to males. Hypokalaemia among cardiovascular diseases was only 22.2% as compared to non-cardiovascular diseases. The mean systolic (142±8) and diastolic Blood pressure (92±2) among cardiovascular diseases was slightly higher as compared with the non-cardiovascular diseases.

Conclusions: Hypokalaemia is significantly associated with myocardial infarction when compared with other disorders. Hypokalaemia was more commonly associated with cardiovascular diseases as compared with non-cardiovascular diseases.



Arrhythmias, Cardiovascular diseases, Hypokalaemia, Potassium

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Keld Kjeldsen. Review Hypokalemia and sudden cardiac death. Exp Clin Cardiol. 2010;15(4):e96-e99.

Paice BJ, Paterson KR, Omara OF, Donnelly T, JM. Gray, D H. Lawson. Record linkage study of hypokalaemia in hospitalized patients. Postgrad Med J. 1986;62:187-191.

Milliez P, Girerd X, Plouin PF, Blacher J, Safar ME, Mourad JJ. Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism. J Am Coll Cardiol 2005;45:1243-8.

Mulatero P, Bertello C, Rossato D , Mengozzi G , Milan A , Garrone C, et al. Roles of clinical criteria, computed tomography scan, and adrenal vein sampling in differential diagnosis of primary aldosteronism subtypes. J Clin Endocrinol Metab. 2008;93:1366-71.

Schulman M, Narins RG. Hypokalemia and cardiovascular disease. Am J Cardiol. 1990;65:4E-9E.

Krakaurer R, Lauritzen M. Diuretic therapy and hypokalemia in geriatric outpatients. Danish Med Bulletin. 1978;26.

Singhi S, Marudkar A. Hypokalemia in a pediatric intensive care unit. Indian Pediatr. 1996;33(1):9-14.

Catena C, Colussi G, Nadalini E, Chiuch A, Baroselli S, Lapenna R, et al. Cardiovascular outcomes in patients with primary aldosteronism after treatment. Arch Intern Med. 2008;168:80-5.

Healy JJ, McKenna TJ, Canning BS, Brien TG, Duffy GJ, Muldowney FP. Body composition changes in hypertensive subjects on long-term oral diuretic therapy. Br Med J. 1970;1(5698):716-9.

Down PE, Polak A, Rad R, Mead JA. Fate of potassium supplements in six patients receiving long term diuretics for oedematous disease. Lancet. 1972;ii:721.