A clinical and biochemical study of dengue fever in Kosi region of Bihar, India


  • Rakesh Kumar Department of Physiology, Katihar Medical College and Hospital, Katihar, Bihar, India
  • Shanker Suman Department of Medicine, Katihar Medical College and Hospital, Katihar, Bihar, India
  • Rajiv Ranjan Department of Physiology, Katihar Medical College and Hospital, Katihar, Bihar, India




Aedes aegypti, Dengue fever, Diarrhoea, Headache, Nausea


Background: Dengue is a debilitating arthropod-borne viral (arboviral) disease in humans. To improve diagnostics for patients with dengue so that they can receive effective treatments at earliest. In addition, a better understanding of clinical and biochemical study of dengue cases, effective measures can be aimed for the prevention and control of dengue epidemics.

Methods: A retrospective clinical and laboratory study was undertaken among admitted patients in the Department of Physiology at Katihar Medical College and Hospital, Katihar, Kosi region of Bihar, India. Forty-two (42) patients admitted over a period of two years, with laboratory results for NS1 antigen and or /IgM positive, for dengue fever, were taken in the study. Clinical features, haematological and biochemical parameters were noted.

Results: Out of the 42 patients, 38 patients were male (90.4%) and 4 patients were female (9.6%). Pyrexia was the major symptom (100%) followed by splitting headache (90.40%), myalgia (76.19%), conjunctival redness (50.00%), skin rash (42.80%), abdominal pain (30.95%), hepatosplenomegaly (28.57) ascites (26.19%) and retro orbital pain (19.04%). Severe thrombocytopenia (69.51%), leukopenia (20.19%) and elevated serum SGOT and SGPT (88.54%) were observed.

Conclusions: Dengue infection is increasing proportional to increased urbanization and compromised sanitation measures. Fever associated with headache, retro orbital pain, erythematous morbilliform rash, conjunctival redness and itching in palms and soles along with thrombocytopenia, leukopenia, elevated SGPT should prompt a clinician on the possibility of dengue infection.

Author Biography

Rakesh Kumar, Department of Physiology, Katihar Medical College and Hospital, Katihar, Bihar, India



Tseng YT, Chang FS, Chao DY, Lian I. Re-model the relation of vector indices, meteorological factors and dengue fever. J Trop Dis. 2016;4(200):2.

Dar W, Sofi P, Ahmad R, Chauhan G, Singh S, Dua D. A rare complication of dengue fever. J Gen Pract. 2016;4:1-2.

Khoj L, Baksh R, Aslam M, Kelta M, Albeirouti B, Rehman JU. A case of dengue fever-induced severe aplastic anemia salvaged by allogenic bone marrow transplant. J Leuk. 2013;1:1-3.

Avasthi G, Prashant B, Rahul K, Vinay S. A case of immune complex mediated acute kidney injury occurring in the first few days of dengue fever. J Clin Case Rep. 2012;2(228):2.

Pruthvi D, Shashikala P, Shenoy V. Evaluation of platelet count in dengue fever along with seasonal variation of dengue infection. J Blood Disord Transf. 2012;3:128.

Alcon S, Talarmin A, Debruyne M, Falconar A, Deubel V, Flamand M. Enzyme-linked immunosorbent assay specific to dengue virus type 1 non-structural protein ns1 reveals circulation of the antigen in the blood during the acute phase of disease in patients experiencing primary or secondary infections. J Clin Microbiol. 2002;40(2):376-81.

Duan T, Ferguson M, Yuan L, Xu F, Li G. Human monoclonal fab antibodies against west Nile virus and its neutralizing activity analysed in vitro and in vivo. J Antivir Antiretrovir. 2009;1(1):36-42.

Howell G, Torre CA, Munayco-Escate C, Suarez-Ognio L, Lopez-Cruz R, Hyman JM, et al. Spatial and temporal dynamics of dengue fever in Peru. Epidemiol infect. 2008;136(12):1667-77.

Suzzane MS. Dengue. Medscape. Retrieved 4/10/2014. Available at http:// emedicine. medscape.com/article/215840.

Kyle JL, Harris E. Global spread and persistence of dengue. Annu Rev Microbiol. 2008;62:71-92.

Gubler DJ. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev. 1998;11:480-96.

Munde DD, Shetkar UB. Clinical features and Hematological Profile of Dengue Fever. Indian J Appl Res. 2013;3:131-2.

Mandal SK, Ganguly J, Sil K, Chatterjee S, Chatterjee K, Sarkar P, et al. Clinical profiles of dengue fever in a teaching hospital of eastern India. Nat J Med Res. 2013;40:16-42.

Azfar NA, Malik LM, Jamil A, Jahangir M, Tirmizi N, Majid A, et al. Cutaneous manifestations in patients of dengue fever. J Pak Assoc Dermatol. 2012;22(4):320-4.

Muniraja PK, Swapna M, Mashyastha R. Clinical Manifestations and Biochemical profile of Dengue Fever in a Tertiary Care Centre. Internal J Clin Cases Invest. 2013;5:72-82.

Ahmed S, Ali N, Ashraf S, Ilyas M, Tariq WU, Chotani RA. Dengue fever outbreak: a clinical management experience. J Coll Physicians Surg Pak. 2008;18(1):8-12.

Kularatne SA, Gawarammana IB, Kumarasiri PR. Epidemiology, clinical features, laboratory investigations and early diagnosis of dengue fever in adults: a descriptive study in Sri Lanka. Southeast Asian J Trop Med Public Health. 2005;36:686-92.

Silva EM, Conde JN, Allonso D, Nogueira ML, Mohana-Borges R. Mapping the interactions of dengue virus NS1 protein with human liver proteins using a yeast two-hybrid system: identification of C1q as an interacting partner. PLoS One. 2013;8(3):e57514.

Muniraja PK, Swapna M, Mashyastha R. Clinical manifestations and biochemical profile of dengue fever in a tertiary care centre. Internal J Clin Cases Invest. 2013;5:72-82.






Original Research Articles