DOI: http://dx.doi.org/10.18203/2349-3933.ijam20173233

Status of vitamin D3 level and its co-relation with the glycaemic status in Indian population

Richa Giri, Rajendra Kumar Verma, Arisht Jain, Vaibhava Srivastava

Abstract


Background: The growing incidence of diabetes, consequent devastating morbidity, increasing mortality highlight the need for innovative approaches for prevention and management of disease. Pleiotropic hormonal effect of vitamin D3 has speculated its role in pathogenesis of diabetes. This study aims to assess vitamin D3 levels in study and control group and co-relate its level with HbA1c.

Methods: This is a cross-sectional observational study done on randomly selected patients from January 2015 to September 2016. Patients were divided into 2 groups: control group and study group including pre-diabetics and diabetics. Venous sample for serum 25-OH vitamin D and HbA1c were collected.

Results: 109 subjects were included in the study: 37 controls, 41 pre-diabetics, 31 diabetics. Out of the 37 healthy subjects, 14 (37.9%) had sufficient levels, 11 (29.7%) had insufficient levels whereas 12 (32.4%) were deficient in Serum vitamin D3 levels. Vitamin D3 deficiency was prevalent in 46.3% pre-diabetics, 41.7% diabetics with good glycaemic control and 84.2% diabetics with poor glycaemic control.

Conclusions: Using Pearson Chi square, inverse co-relation was found between glycated haemoglobin and vitamin D3 levels (p<0.003).


Keywords


Diabetes, Glycaemic status, HbA1c, Pre-diabetes, Vitamin D3

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