Status of vitamin D3 level and its co-relation with the glycaemic status in Indian population


  • Richa Giri Department of Medicine, GSVM Medical College, Kanpur, Uttar Pradesh, India
  • Rajendra Kumar Verma Department of Medicine, GSVM Medical College, Kanpur, Uttar Pradesh, India
  • Arisht Jain Department of Medicine, GSVM Medical College, Kanpur, Uttar Pradesh, India
  • Vaibhava Srivastava Department of Medicine, GSVM Medical College, Kanpur, Uttar Pradesh, India



Diabetes, Glycaemic status, HbA1c, Pre-diabetes, Vitamin D3


Background: The growing incidence of diabetes, consequent devastating morbidity, increasing mortality highlight the need for innovative approaches for prevention and management of disease. Pleiotropic hormonal effect of vitamin D3 has speculated its role in pathogenesis of diabetes. This study aims to assess vitamin D3 levels in study and control group and co-relate its level with HbA1c.

Methods: This is a cross-sectional observational study done on randomly selected patients from January 2015 to September 2016. Patients were divided into 2 groups: control group and study group including pre-diabetics and diabetics. Venous sample for serum 25-OH vitamin D and HbA1c were collected.

Results: 109 subjects were included in the study: 37 controls, 41 pre-diabetics, 31 diabetics. Out of the 37 healthy subjects, 14 (37.9%) had sufficient levels, 11 (29.7%) had insufficient levels whereas 12 (32.4%) were deficient in Serum vitamin D3 levels. Vitamin D3 deficiency was prevalent in 46.3% pre-diabetics, 41.7% diabetics with good glycaemic control and 84.2% diabetics with poor glycaemic control.

Conclusions: Using Pearson Chi square, inverse co-relation was found between glycated haemoglobin and vitamin D3 levels (p<0.003).

Author Biography

Richa Giri, Department of Medicine, GSVM Medical College, Kanpur, Uttar Pradesh, India

Department of Medicine, Assistant Professsor


Hu FB. Globalization of diabetes: the role of diet, lifestyle, and genes. Diab Care. 2011;34(6):1249-57.

Abraham TM, Fox CS. Implications of rising prediabetes prevalence. Diab Care. 2013;36(8):2139-41.

American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diab Care. 2013;36(suppl. 1):S67-S74.

Wallace TM, Matthews DR. Poor glycaemic control in type 2 diabetes: a conspiracy of disease, suboptimal therapy and attitude. QJM. 2000;93(6):369-74.

Montane J, Cadavez L, Novials A. Stress and the inflammatory process: a major cause of pancreatic cell death in type 2 diabetes. Diabetes Metab Syndr Obes. 2014;7:25-34.

Harrison’s Principles of Internal Medicine. 19th edition. Vitamin and trace mineral deficiency and excess; 2015:96e-7.

Deleskog A, Hilding A, Brismar K, Hamsten A, Efendic S, Östenson CG. Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance. Diabetologia. 2012;55:1668-78.

Forouhi NG, Luan J, Cooper A, Boucher BJ, Wareham NJ. Baseline serum 25-hydroxy Vitamin D is predictive of future glycaemic status and insulin resistance. Diabetes. 2008;57(10):2619–25.

Song Y, Wang L, Pittas AG, Del Gobbo LC, Zhang C, Manson JE, et al. Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care. 2013;36:1422-8.

Gupta A. Vitamin D deficiency in India: prevalence, causalities and interventions. Nutrients. 2014;6(2):729-75.

Harinarayan CV, Ramalakshmi T, Venkataprasad U. High prevalence of low dietary calcium and low vitamin D status in healthy south Indians. Asia Pac J Clin Nutr. 2004;13:359-64.

Dutta D, Mondal SA, Choudhuri S, Maisnam I, Hasanoor Reza AH, Bhattacharya B, et al. Vitamin-D supplementation in prediabetes reduced progression to type 2 diabetes and was associated with decreased insulin resistance and systemic inflammation: An open label randomized prospective study from Eastern India. Diabetes Res Clin Pract. 2014;103:e18–23.

Kumar RA, Narasimhasetty KR, Bhende PV, Lalitha R, Shetty SB. Prevalence of vitamin D deficiency in south Indian type 2 diabetes individuals. Int J Clin Cases and Invest. 2013;5(4)(15):19.

Bayani MA, Akbari R, Banasaz B, Saeedi F. Status of Vitamin-D in diabetic patients. Caspian J Intern Med. 2014;5(1):40-2.

Kostoglou-Athanassiou I, Athanassiou P, Gkountouvas A, Kaldrymides P. Vitamin D and glycemic control in diabetes mellitus type 2. Ther Adv Endocrinol Metab. 2013;4(4):122-8.






Original Research Articles