DOI: http://dx.doi.org/10.18203/2349-3933.ijam20173246

A study of treatment outcomes of pulmonary tuberculosis and extrapulmonary tuberculosis patients in a tertiary care centre

V. H. Ramya, G. Gayathri, V. Gangadharan

Abstract


Background: Directly observed treatment remains one of the most widely-accepted global health interventions for tuberculosis. Tuberculosis treatment outcome is one of the performance indicators of the programme set by World Health Organization.

Methods: This study was conducted in a tertiary care centre Chennai. A retrospective analysis of the profile and treatment outcome of all tuberculosis patients registered from January 2015 to December 2015 at DOTS centre under RNTCP was conducted. Data on treatment outcomes was analysed using appropriate statistical methods and percentages were calculated.

Results: Out of 118 TB cases, 59.3% had pulmonary while 40.7% had extra-pulmonary TB. Sputum positive PTB is more common than sputum negative which is 74.2% and 25.8% respectively. Frequency of TB lymphadenitis is being the common presentation among extra pulmonary TB cases, followed by TB pleurisy. Success rate (cure rate plus treatment completion rate) for new cases was 63.1% and for retreatment cases was 36.9% while the overall success rate was 81%.

Conclusions: Effective measures have to be taken in the programme to move forward to help in the eradication of TB. Tuberculosis mostly affects males of the economically productive age group and causes economic losses. The success rate of new cases was higher compared to retreatment cases though the overall success rate was lower compared to the RNTCP norms. Proper education on DOTS can help in improving the success rate and cure rate.


Keywords


DOTS, Treatment outcome, Tuberculosis, Tertiary care centre

Full Text:

PDF

References


WHO. Global Tuberculosis Report 2016. Cdc 2016 [Internet]. 2016; (Global TB Report2016). Available at: http://scholar.google.com/scholar?hl=en& btnG=Search&q=intitle:No+Title#0.

WHO: Tuberculosis fact sheet. WHO: 2016.

TB Statistics for India: National and state statistics. Available from: http://www.tbfacts.org/tb-statisticsindia/

Global Tuberculosis Control: Surveillance, planning, financing. WHO Report 2010, World Health Organization, Geneva, Switzerland, 2010.

Corbett EL, Watt CJ, Walker N. “The growing burden of tuberculosis: global trends and interactions with the HIV epidemic.” Archives of Internal Medi. 2003;163(9):1009-21.

Dye C, Espinal MA, Watt CJ, Mbiaga C, Williams BG. Worldwide incidence of multidrug-resistant tuberculosis. J Infect Dis. 2002;185(8):1197-1202.

Frieden TR, Sterling TR, Munsiff SS, Watt CJ, Dye C. Tuberculosis. Lancet. 2003;362(9387):887-99.

Dooley KE, Tang T, Golub JE, Dorman SE, Cronin W. Impact of diabetes mellitus on treatment outcomes of patients with active tuberculosis. Am J Trop Med Hyg. 2009;80:634-639.

Veen J, Raviglione M, Riederetal HL. Standardized tuberculosis treatment outcome monitoring in Europe. Eu Res J. 1998;12(2):505-10.

Definitions and reporting framework for tuberculosis; 2013.

García-Elorriaga and Del Rey-Pineda. Type 2 diabetes mellitus as a risk factor for tuberculosis. J Mycobac Dis. 2014;4:2.

Akarkar NS, Pradhan SS, Ferreira AM. Treatment outcomes among tuberculosis patients at an urban health centre, Goa, India: eight-year retrospective record based study. IJCMPH. 2017;4(3):831-34.

Chennaveerappa PK, Siddharam SM, Halesha BR, Vittal BG, Jayashree N. Treatment outcome of tuberculosis patients registered at DOTS centre in a teaching hospital, South India. Int J Biol Med Res. 2011;2(2):487-9.

Veeramani G, Madhusudhan S. Study on outcome of the treatment of tuberculosis patients registered under revised national tuberculosis control programme: DOTS strategy. J Pharm Sci Res. 2016;8(1):53-8.

Khan NM, Sonkar VK, Domple VK, Gujrathi VV, Inamdar IF. Evaluation of treatment outcome of tuberculosis patients in the municipal corporation area of Nanded City. IJPPHS. 2016;2(1):8-10.

Costa AL Da, Keny SJ, Lawande D. Treatment outcome of pulmonary and extra pulmonary tuberculosis patients in TB and chest disease hospital DOT centre, Goa, India. Int J Curr Microbiol Appl Sci. 2016;5(4):437-41.

Sharma SK, Mohan A. Extrapulmonary tuberculosis. Indian J Med Res. 2004;120:316-53.

Su SB, Chiu CF, Chang CT, Chen KT, Lin CY, Guo HR. Screening for pulmonary tuberculosis using chest radiography in new employees in an industrial park in Taiwan. Am J Infect Control. 2007;35(4):254-9.

Using chest radiography in new Employees in an industrial park In Taiwan American Journal of Infection Control. Tuberculosis treatment success rate (% of new cases) World Health Organization, Global Tuberculosis Control Report.

Revised national tuberculosis control programme. Technical and operational guidelines for tuberculosis control in India; 2016.