Diaphragmatic dysfunction: an unusual complication in HELLP syndrome
DOI:
https://doi.org/10.18203/2349-3933.ijam20181088Keywords:
Acute respiratory problems, Diaphragmatic dysfunction, HELLP syndromeAbstract
Diaphragmatic dysfunction in HELLP [hemolysis (H), elevated liver enzymes (EL), low platelet count (LP)] Syndrome and Diaphragmatic dysfunction is an uncommonly reported association, wherein, patients who develop acute respiratory insufficiency poses a delay in weaning without any obvious cause. A high degree of clinical suspicion of sepsis induced diaphragmatic dysfunction needs to be kept in mind by the clinicians dealing with cases of HELLP Syndrome who may develop acute respiratory insufficiency without definite predisposing factors.
References
Weinstein L. Syndrome of hemolysis, elevated liver enzymes and low platelet count: a severe consequence of hypertension in pregnancy. Am J Obstet Gynecol. 2005;193:859.
Satpathy HK, Satpathy C, Donald F. Hellp syndrome. J Obstet Gynecol India. 2009;59(1):30-40.
Haram K, Svendsen E, Abildgaard U. The HELLP syndrome: Clinical issues and management. A Review. BMC Pregnancy Childbirth. 2009;9:8.
Mihu D, Costin N, Mihu CM, Seicean A, Ciortea R. HELLP Syndrome-A Multisystemic Disorder. J Gastrointestin Liver Dis. 2007;16(4):419-24.
Sibai BM. Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count. Obstet Gynecol. 2004;103(5) Part-I:981-91.
Pokharel SM, Chattopadhyay SK, Jaiswal R and Shakya P. HELLP Syndrome-a pregnancy disorder with poor prognosis. Nepal Med Coll J. 2008;10(4):260-3.
Hussain SN, Simkus G, Roussos C. Respiratory muscle fatigue: a cause of ventilatory failure in septic shock. J Appl Physiol. 1985;58:2033-40.
Hammoud GM, Ibdah JA. Preeclampsia-induced liver dysfunction, HELLP syndrome, and acute fatty liver of pregnancy. Clin Liver Dis. 2014;4(3):69-73.
Callahan, Leigh A, Supinski, Gerald S. Sepsis-induced myopathy. Critical Care Medicine 2009;37(10):S354-67.
Callahan LA, Supinski GS. Sepsis induces diaphragm electron transport chain dysfunction and protein depletion. Am J Respir Critic Care Med. 2005; 172:861-8.
