Serum C- reactive protein level and lipid profile in periodontitis and coronary artery disease in people of Bhuj region

Dinesh Dave; Vishal Desai

doi:10.18203/2349-3933.ijam20174291

Authors

Dinesh Dave Department of Medicine, Gujarat Adani Institute of Medical Science, Bhuj, Gujarat, India
Vishal Desai Department of Medicine, Gujarat Adani Institute of Medical Science, Bhuj, Gujarat, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20174291

Keywords:

C-reactive protein, Coronary artery disease, Lipid metabolism, Periodontitis

Abstract

Background: Many epidemiological studies have investigated the relationship between periodontal disease and coronary artery disease but their result is heterogeneous. This review article is designed to update the association between periodontal disease and cardiovascular events. Hence, the aim of the present study was to assess whether there is a link between periodontal and coronary artery disease (CAD).

Methods: This study includes 90 subjects, which were divided into 3 groups: 30 subjects -healthy individuals, 30 subjects- having Periodontitis, 30 subjects- suffering from coronary artery diseases.

Results: The mean OHI-S scores for group 1, 2 and 3 were 0.95±0.60, 2.91±0.90, 1.54±0.74 respectively. CRP level group 2 and 3 were significantly higher than group 1 (p =0.002 and 0.00 respectively) whereas difference between group 2 and 3 was not significantly significant. Lipid profiles, cholesterol, low density lipoprotein (LDL), triglycerides higher in group 2 as compare to 1 and 3. High density lipoprotein (HDL) levels between groups were not significantly different.

Conclusions: Based on results and other reports Periodontitis may be a risk factor for CAD and possibly there can be an association between periodontal diseases.

Metrics

Metrics Loading ...

References

Bullon P, Newman HN, Battino M. Obesity, diabetes mellitus, atherosclerosis and chronic periodontitis: a shared pathology via oxidative stress and mitochondrial dysfunction? Periodontol. 2014;64:139-53.

Mehta JL, Saldeen TG, Rand K. Interactive role of infection, inflammation and traditional risk factors in atherosclerosis and coronary artery disease. J Am College Cardiol. 1998;31:1217-25.

London GM. The clinical epidemiology of cardiovascular diseases in chronic kidney disease: cardiovascular disease in chronic renal failure: pathophysiologic aspects. Seminars Dialysis. 2003;16(2):85-94.

Anjanaa R, Suresha R. Periodontal infection, a risk for coronary artery disease. SRJM. 2010;3:12-9.

Barbara MA. Periodontal disease and rheumatoid arthritis; a pilot study using self-reported questionnaire; 2016.

Islam A, Rahman M, Ullah M, Yeasmin L. Link between periodontal disease and coronary artery disease. Bangladesh Perspective. 2014;7(10):44-54.

Sharma A, Astekar M, Metgud R, Soni A, Verma M, Patel S. A study of C-reactive protein, lipid metabolism and peripheral blood to identify a link between periodontitis and cardiovascular disease. Biotechnic Histochemistry. 2014;89:577-82.

Thompson GR, Soutar AK, Spengel FA, Jadhav A, Gavigan SJ, Myant NB. Defects of receptor-mediated low-density lipoprotein catabolism in homozygous familial hypercholesterolemia and hypothyroidism in vivo. Proceedings National Academy Sci. 1981;78(4):2591-5.

Rizos CV, Elisaf MS, Liberopoulos EN. Effects of thyroid dysfunction on lipid profile. Open Cardiovascular Med J. 2011;5:76.