DOI: http://dx.doi.org/10.18203/2349-3933.ijam20174292

A study on urinary tract infection in a tertiary care hospital

V. Rajendran, R. Nepoleon, Prashant V. Solanke, M. Shahbaz Zailu, P. Valli

Abstract


Background: Urinary tract infection is defined as bacteriuria along with urinary symptoms. It is one of the most common bacterial infections in humans and a major cause of morbidity. UTI has become difficult to treat because of appearance of pathogens with increasing resistance to antimicrobial agents. The objective of this study was to determine the bacteriological profile of pathogens responsible for urinary tract infection and to assess the antibiotic sensitivity pattern of the causative uropathogens.

Methods: This cross-sectional study was performed at the hospital of Sree Mookambika Institute of Medical Sciences, Kulasekharam during January 1, 2016 to December 12, 2016. Institutional ethical committee clearance was obtained. We surveyed 628 patients, who had clinical manifestations of UTI. Urine specimens were cultured for isolation of the microbial agents of UTI. The isolated bacteria were identified using biochemical tests. Data was entered in Microsoft Excel Version 2016.Statistical analysis was done using SPSS TRIAL VERSION 21C.

Results: The commonest organism isolated overall was extended spectrum beta lactamase positive E. coli (35.5%) followed by extended spectrum beta lactamase negative E. coli and Enterococcus. Females (68.63%) were mostly affected than males in our study. The people in the age group of 41-60 years are found to be more (48.46%) affected than the people of other age groups. The most sensitive oral antibiotic to almost all organisms in our study is Nitrofurantoin followed by Cotrimoxazole and Norfloxacin and among parenteral antibiotics, Amikacin stands first followed by Piperacillin-Tazobactam and Gentamicin. Apart from the above antibiotics, Klebsiellapnemoniae also shows good response to Cefotaxime (96.15%) and Cefipime (96.15%) and Aztreonam (92.3%).

Conclusions: From our study, it is observed that the most common causative organism for Urinary tract infection is found to be extended spectrum beta lactamase positive E. coli followed by Extended Spectrum Beta Lactamase negative E. coli and Enterococcus. The current status of sensitivity of common organism rests mainly on Nitrofurantoin (oral) and Amikacin, Piperacillin-Tazobactam (parenteral).


Keywords


Antibiotic sensitivity, Bacteria, Urinary tract infection, Uropathogens

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References


Angami S, Jamir N, Sarma PC, Deka. Urinary tract infection, its causative microorganism and antibiotic susceptibility in Nagaland. Arch Med Health Sci. 2015;3(1):40-3.

Jubina Bency AT, Priyanka R, Jose P. A study on the bacteriological profile of urinary tract infection in adults and their antibiotic sensitivity pattern in a tertiary care hospital in central Kerala. Int J Res Med Sci. 2017;5(2):666-9.

Angoti G, Goudarzi H, Hajizadeh M, Tabatabaii Z. Bacteria isolated from urinary tract infection among patients and determination of the antibiotic susceptibility patterns of the gram negative bacteria in Iran. Novelty Biomed. 2016;1:1-4.

Prakash D, Saxena RS. Distribution and antimicrobial susceptibility pattern of bacterial pathogens causing urinary tract infection in urban community of Meerut city. ISRN Microbiol. 2013:Article ID 749629.

Yasmeen BHN, Islam S, Uddin MM, Jahan R. Prevalence of urinary tract infection, its causative agents and antibiotic sensitivity pattern. Northern Int Medi Colle J. 2015;7(1):105-9.

Maji SK, Mandal PK, Panja C, Dolai TK, Samanta A, Kundu PK, et al. Studies on drug sensitivity and bacterial prevalence of UTI in tribal population of Paschim Medinipur. Int J Curr Microbiol App Sci. 2016;5(6):406-12.

Hryniewicz K, Szczypa K, Sulikowska A, Jankowski K, Betlejewska K, Hryniewicz W. Antibiotic susceptibility of bacterial strains isolated from urinary tract infections. J Antimicrob Chemother. 2001;47(6):773-80.

Farajnia S, Alikhani MY, Ghotaslou R, Naghili B, Nakhlband A. Causative agents and antimicrobial susceptibilities of UTI Northwest Iran. Int J Infect Dis. 2009;13(2):140-4.

Akter T, Mia Z, Shahriar M. Antibiotic sensitivity of pathogens causing urinary tract infection Bangladesh Pharmaceutical J. 2013;16(1):53-8.

Beyene G, Tsegaye W. Bacterial uropathogens in urinary tract infection and antibiotic susceptibility pattern in Jimma University Specialized Hospital, Southwest Ethiopia: Ethiop J Health Sci. 2011;21(2):141-6.

Niranjan V, Malini A. Antimicrobial resistance pattern in Escherichia coli causing urinary tract infection among inpatients. Indian J Med Res. 2014;139(6):945-8.

Tada Dharmishtha G, Gandhi Paragi J, Patel Kiran N. A study on antibiotic related resistance in uti patients. National J Community Med. 2012;3(2):255-8.

Razak SK, Gurushantappa V. Bacteriology of urinary tract infection and antibiotic susceptibility pattern in a tertiary care hospital in South India. Int J Med Sci Public Health. 2012;1(2):109-12.

Onoh RC, Umeora OUJ, Egwuatu VE, Ezeonu PO, Onoh TJP. Antibiotic sensitivity pattern of uropathogens from pregnant women with urinary tract infection in Abakaliki, Nigeria. Infect Drug Resist. 2013;6:225-33.