Genetic polymorphisms of CYP3A4*1B of cervical cancer patients in Bangladeshi population, Bangladesh

Shamim Md. Abdullah; Hossain Md. Shafayat; Sazib Md. Saifuzzaman; Shahariar Md. Fahim; Hossain Md. Golam

doi:10.18203/2349-3933.ijam20161463

Authors

Shamim Md. Abdullah Pharmacy Discipline, Khulna University, Khulna, Bangladesh
Hossain Md. Shafayat PhD scholar, IGDB, CAS, Beijing, China
Sazib Md. Saifuzzaman Pharmacy Discipline, Khulna University, Khulna, Bangladesh
Shahariar Md. Fahim Pharmacy Discipline, Khulna University, Khulna, Bangladesh
Hossain Md. Golam Pharmacy Discipline, Khulna University, Khulna, Bangladesh

DOI:

https://doi.org/10.18203/2349-3933.ijam20161463

Keywords:

Genetic polymorphism, CYP3A4*1B, Cervical cancer, DNA, Restriction enzyme

Abstract

Background: Cervical cancer incidence rate in Bangladesh is 15.9 and age-standardized incidence rate is 19.2 (rates per 1,00,000 women per year). Polymorphisms of different genes have been affirmed to be associated with cervical cancer. Our prime purpose is to observe whether CYP3A4*1B polymorphisms are related with increasing cervical cancer risk in Bangladeshi population. The compilation of precise clinical information allows the clarity of different clinical phenotypes, which play a vital role in genetic studies of cervical cancer.

Methods: The study was a case-control study carried out between patients and volunteers matched by age, sex, height, weight and smoking status. Daly’s chemical method was used to isolate genomic DNA from venous blood. The demographic variables of cases and controls were put side by side using chi-square tests and Student’s t tests.

Results: Odds ratio and 95 % confidence interval were assigned to estimate the risk of cervical cancer. CYP3A4*1B polymorphisms and cervical cancer risk do not show any considerable relationship. The polymorphic frequencies of CYP3A4*1B allele (normal homozygote, heterozygote and mutant homozygote) in cervical cancer were 60%, 40% and 0% respectively; frequencies in control were 66.67%, 33.33% and 0% respectively (p<0.05). Finally, we conclude that CYP3A4*1B polymorphisms is not associated in susceptibility to developing cervical cancer, at least in Bangladeshi population.

Conclusions: In brief, the consequences of our study demonstrated that CYP3A4*1B polymorphism is not allied in susceptibility to develop cervical cancer, at least in Bangladeshi women.

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