Comparative study on effect of oral hypoglycemics and insulin treatment on quality of life among diabetic subjects


  • Harish Kumar S. Department of Medicine, Sri Devaraj URS Medical College, Kolar, Karnataka, India
  • Srinivasa S. V. Department of Medicine, Sri Devaraj URS Medical College, Kolar, Karnataka, India
  • Prabhakar K. Department of Medicine, Sri Devaraj URS Medical College, Kolar, Karnataka, India



Diabetes mellitus, Insulin, Oral Hypoglycaemic agents, QoL


Background: Diabetes is a chronic non-communicable disease with variable presentation and complications. It is well known that over a period of time complications sets in and causes substantial decrease in the patient’s quality of life (QoL). QoL domains plays and important factor in prediction of outcome of diabetic treatment. Hence this study was conducted with the objectives to find the difference in quality of life (QoL) domains in diabetics on oral hypoglycaemic agents and Insulin.

Methods: Longitudinal Study was undertaken in tertiary care centre, for duration of 6 months. Type 2 Diabetics on treatment with oral hypoglycemics and Insulin were included in the study. Socio - demographic profile, laboratory investigations were collected using structured and pretested questionnaire. Quality of life was assessed by WHOQOL-BREF. SPSS 22 version, EPI Info and Open EPI software were used for Statistical analysis. Chi-square and Students t-test were the statistical tests.

Results: 59 diabetic subjects were included in Oral and insulin group respectively. Mean age of oral hypoglycemics was 59.6±8.7 years and Insulin group was 61.4±8.2 years. Age and gender were matched between two groups. Glycemic profile was significantly higher in Oral group than in Insulin group. Physical domain was significantly higher (better) in oral group than in Insulin group. Psychological and Social domain was significantly higher (better) in Insulin group. Hence QoL is affected by type of hypoglycaemic agent used among diabetics.

Conclusions: Quality of life with respect to physical domain was reduced in Insulin group, were as psychological and social domain was reduced in Oral group.


Nagpal J, Kumar A, Kakar S, Bhartia A. The development of quality of life instrument for indian diabetes patients (QOLID): a validation and reliability study in middle and higher income groups. JAPI. 2010;58:295-304.

Harkreader H. Fundamentals of nursing: caring and clinical judgment, 3rd Edn, Philadelphia, Lippincott; 2007:48-52.

Fal AM, Jankowska B, Uchmanowicz I. Type 2 diabetes quality of life patients treated with insulin and oral hypoglycemic medication. BMC Pub Health. 2011:237-42.

Rubin RR, CDE. Diabetes and quality of life. Diabet Spect. 2000;13:21.

Orley J. Introduction, administration, scoring and generic version of the assessment field trial version. Programme on mental health. World Health Organization; 1996:41-57.

The World Health Organization Quality of Life (WHOQOL)-BREF. World Health Organization 2004:3-5.

World Health Organization. Definition, diagnosis and classification of diabetes mellitus and its complications: Report of a WHO Consultation, 1999. Available at http:// www.whqlibdoc. Accessed on 25 July 2017.

The IDF consensus worldwide definition of the metabolic syndrome 2006. Available at Accessed on 24 July 2017.

Misra A, Wasir JS, Pandey RM. An Evaluation of candidate definitions of the metabolic syndrome in adult Asian Indians. Diabetes Care. 2005;28:398-403.

Chaveepojnkamjorn W, Pichainarong N, Schelp F. Quality of life and compliance among type 2 diabetic patients. Southeast Asian J Trop Med Public Health. 2008;39(2):328-34.

Papadopoulos A, Kontodimopoulos N, Frydas A. Predictors of health-related quality of life in type II diabetic patients in Greece. BMC Pub Health. 2007;7:186.

Fal AM, Jankowska B, Uchmanowicz I, Sen M, Panaszek B, Polanski J. Type 2 diabetes quality of life patients treated with insulin and oral hypoglycemic medication. Acta Diabetol. 2011;48(3):237-42.

Nadeau J, Koski K, Strychar I, Yale JF. Teaching subject with type 2 diabetes how to incorporate sugar choices into their daily meal plan promotes dietary compliance and does not deteriorate metabolic profile. Diabet Care. 2001;24:222-7.

Redekop WK, Koopmanschap MA, Stolk RP, Rutten GE, Wolffenbuttel BH, Niessen LW. Health related quality of life and treatment satisfaction in Dutch patients with type 2 diabetes. Diabet Care. 2002;25(3):458-63.

Brown GC, Brown MM, Sharma S. Quality of life associated with diabetes mellitus in an adult population. J Diabet Popul. 2002;14:18-24.

Stewart ST, Woodward RM, Cutler DM. A proposed method for monitoring US population health: linking symptoms, impairments, chronic conditions, and health ratings. National Bureau of Economic Research Working Paper 11358. Cambridge, MA: National Bureau of Economic Research; 2005.

Rubin RR, Peyrot M. Quality of life and diabetes. Diabet Metab Res Rev. 1999;15:205-18.






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