A study to find out the relationship between insulin resistance and hypertension

Zakir Hussain, Vishwa Deepak Tripathi


Background: Insulin resistance is the essential defect in the development of type 2 diabetes mellitus, hypertension and cardiovascular diseases. The aim of the present study was to evaluate the correlation between insulin resistance, metabolic syndrome and their associated factors in hypertensive patients.

Methods: This comparative study was conducted on 100 patients who attended to the Department of Medicine, NSCB Medical College, Jabalpur, Madhya Pradesh, India. 50 patients of both sexes having essential hypertension were participated in the study and considered as hypertensive group. Other healthy 50 patients of similar sex and age group were studied as control group (normotensive) for comparison. Insulin resistance was estimated by using homeostasis model assessment (HOMA-IR) method.

Results: Mean age of the patients of hypertensive group was 49.79±17.04 years and mean age of normotensive group was 51.94±16.64 years. Male preponderance was observed in both the groups. Out of 50 from each group, 19 (38%) of hypertensive patients and 7 (14%) of normotensive patients had insulin resistance. Metabolic syndrome was noted in 23 (46%) and 10 (20%) cases of hypertensive and normotensive groups respectively and this difference was found to be statistically significant (p=0.01). The mean fasting and post prandial blood sugar levels were almost similar in both groups (p=0.03). Mean total cholesterol levels were significantly lower in hypertensive groups than that of normotensive group (p=0.03). The mean serum insulin levels were high in hypertensive groups than that of normotensive group which was statistically significant (p=0.00). Mean HOMA-IR, waist size and waist hip ratio (WHR) was significantly (p=0.02) higher in hypertensive group than that of control group.

Conclusions: The results of the present study support the strong correlation between insulin resistance and essential hypertension and also confirmed that insulin resistance was the major risk factor of metabolic syndrome. 


Correlation, Hypertension, Insulin resistance

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