Published: 2017-11-22

Sagittal sinus thrombosis secondary to varicella infection-a case report

Gurinder Mohan, Harharpreet Kaur, Navjot Kaur


Varicella zoster virus (VZV) is known to produce a benign self-limiting exanthematous illness in the pediatric population. The neurological complications which are seen in less than 1% cases include cerebellitis and encephalitis. Stroke due to arterial vasculitis is well known but cerebral venous sinus thrombosis following varicella infection is rarely reported. We present a case of sagittal sinus thrombosis subsequent to varicella infection. The mechanisms underlying cerebral vascular events after VZV infection could be vasculitis, thrombosis due to direct endothelial damage and acquired protein S deficiency.


Sagittal sinus thrombosis, Varicella infection

Full Text:



Nagel MA, Gilden D. Update on varicella zoster virus vasculopathy. Cur Infect Dis Rep. 2014;16(6):407.

Kurugöl Z, Vardar F, Özkinay F, Kavakh K, Özkinay C. Lupus anticoagulant and protein S deficiency in otherwise healthy children with acute varicella infection. Acta Paediatrica. 2000;89(10):1186-9.

Nguyên P, Reynaud J, Pouzol P, Munzer M, Richard O, François P. Varicella and thrombotic complications associated with transient protein C and protein S deficiencies in children. Eur J Pedi. 1994;153:646-9.

Sudhaker B, Dnyaneshwar MP, Jaidip CR, Rao SM. Cerebral venous sinus thrombosis (CVST) secondary to varicella induced hypercoagulable state in a adult. Internal Medicine Inside. 2014;2(1):1.

Sada S, Kammineni A, Kanikannan MA, Afshan J. Cerebral sinus venous thrombosis: A rare complication of primary Varicella zoster virus. Neurol Ind. 2012;60:645-6

Menon B, Goyal R. Cerebral venous thrombosis as a complication of chicken pox. Ann Trop Med Public Health. 2012;5:520-2

Siddiqi SA, Nishat S, Kanwar D, Ali F, Azeemuddin M and Wasay M. Cerebral venous sinus thrombosis: association with primary varicella zoster virus infection. J Stroke Cere Dis. 2012;21:917

Sardana V, Mittal LC, Meena SR, Sharma D, Khandelwal G. Acute Venous Sinus Thrombosis after Chickenpox Infection. JAPI. 2014:81-3.