A study of clinical and etiological profile of infective endocarditis and its correlation with echocardiography in patients of rheumatic heart disease


  • Achyut Sarkar Department of Cardiology, IPGMER, Kolkata, West Bengal, India
  • Prashant Kumar Department of Cardiology, IPGMER, Kolkata, West Bengal, India
  • Somnath Mukherjee Department of Cardiology, IPGMER, Kolkata, West Bengal, India
  • Anurag Passi Department of Cardiology, IPGMER, Kolkata, West Bengal, India
  • Jitendra Kumar Singh Department of Medicine, RIMS, Ranchi, Jharkhand, India




Echocardiography, Infective endocarditis, Rheumatic heart disease


Background: This observational study was to determine the offending microorganisms and clinical profile of infective endocarditis in rheumatic heart disease patients in local population of Jharkhand, the response of disease to medical treatment and to evaluate the prognosis of the cases.

Methods: 25 cases of Rheumatic heart disease, fulfilling the diagnostic criteria for infective endocarditis were studied prospectively with baseline investigations, blood culture and echocardiography and were treated with appropriate antibiotics.

Results: In this study, the mean age observed was 26 year and male patient to female patient ratio was 3.16:1. Aortic valve was the commonest valve to be involved. Cardiac murmurs were present in all patients, splenomegaly was present in 56% of patients but peripheral signs of infective endocarditis were rare. Blood culture was positive in 28% of cases and staphylococcus aureus was the main organism isolated. 23 cases out of 25 cases studied showed vegetations on echocardiography mostly on aortic or mitral valve. In majority of patients (80%) injection Penicillin G and Gentamicin were started in standard recommended dose first on empirical basis but later on suitable antibiotics were started according to sensitivity pattern. Mortality was significantly high (20%).

Conclusions: Fever and constitutional symptoms were the most common presentation. Mild to moderate anemia, leucocytosis, high ESR were very common but, peripheral signs were rarely observed in our study. Staphylococcus was the predominant etiological agent and treatment of endocarditis was more successful when suitable antibiotics were started after culture and sensitivity.

Author Biographies

Achyut Sarkar, Department of Cardiology, IPGMER, Kolkata, West Bengal, India

Department of Cardiology, IPGMER

Prashant Kumar, Department of Cardiology, IPGMER, Kolkata, West Bengal, India

Department of Cardiology, IPGMER

Somnath Mukherjee, Department of Cardiology, IPGMER, Kolkata, West Bengal, India

Department of cardiology, IPGMER

Anurag Passi, Department of Cardiology, IPGMER, Kolkata, West Bengal, India

Department of Cardiology, IPGMER

Jitendra Kumar Singh, Department of Medicine, RIMS, Ranchi, Jharkhand, India

Department of Medicione, RIMS, RANCHI


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Original Research Articles