DOI: http://dx.doi.org/10.18203/2349-3933.ijam20175187

A study of hematological parameters and requirement of platelet transfusion in dengue fever

Yashaswini L. S., Priya .

Abstract


Background: Dengue is a common vector-borne disease in India with significant morbidity & mortality. Thrombocytopenia is a common complication in dengue. Bleeding manifestations in dengue put an immense pressure on both patients and treating physicians. There are no clear guidelines for transfusion of platelets in bleeding patients and role of Platelet transfusion in this condition is a bit controversial.

Methods: It was an observational study done at Sree Rajarajeswari medical college and hospital between 1st May and 31st July 2016. Total of 100 dengue-positive cases were studied with respect to clinical features, laboratory parameters and requirement of platelet transfusion.

Results: Majority of patients were males and in the age group 21-30 years. Fever was present in all cases, with a mean of 3-6 days duration. Epistaxis was the most common bleeding manifestation (43%), Malena being the least (3%). Leucopenia was observed in 52% patients. Thrombocytopenia was seen in 89% of admitted patients and 38% among them had raised aPTT. 53%of patients in our study received platelet transfusion.

Conclusions: Bleeding manifestations have no significant association with severity of platelet count. Severe leucopenia is associated with thrombocytopenia. There is no need of platelet-transfusion in all patients with thrombocytopenia with minor bleeds.

 


Keywords


Bleeding manifestations, Dengue fever, Platelet Transfusion

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References


Goel A, Patel DN, Lakhani KK, Agarwal SB, Aarwal A, Singla S et al. Dengue fever- A dangerous foe. J Indian Acad Clin Med. 2004; 5(3):247-58.

Chaturvedi UC, Nagar R, Shrivastava R. Macrophage and dengue virus: Friend or foe? Indian J Med Res. 2006;124:23-40.

World Health Organization, Special Programme for Research, Training in Tropical Diseases, World Health Organization. Department of Control of Neglected Tropical Diseases, World Health Organization. Epidemic, Pandemic Alert. Dengue: guidelines for diagnosis, treatment, prevention and control. World Health Organization; 2009.

Mukherjee S, Manna K, Datta P, Datta S, Chatterjee P. Dengue fever and its epidemiological characteristics: a study from Eastern India. Int J Community Med Public Health. 2016;3:3588-94.

Raikar SR, Kamdar PK, Dabhi AS. Clinical and laboratory evaluation of patients with fever with thrombocytopenia.Indian J ClinPract. 2013;24:360-3.

Ahmed S, Arif F, Yahya Y, Rehman A, Abbas K, Ashraf S, et al. Dengue fever outbreak in Karachi 2006 - A study of profile and outcome of children under 15 years of age. J Pak Med Assoc. 2008;58:4- 8.

Khan MY. A study of clinical and laboratory profile of dengue fever in a tertiary care hospital, Nizamabad, Telangana State, India. Internat J of Contemp Medic Res. 2016;3(8):2383-8.

Narayanan M, Aravind MA. Dengue fever-clinical and laboratory parameters associated with complications. Dengue bulletin. 2003;27:108-15.

Prathyusha CV, Srinivasa Rao M, Sudarsini P, Uma Maheswara Rao K. Clinico-haematological profile and outcome of dengue fever in children. Int J CurrMicrobiolAppl Sci. 2013;2:338-46.

Kumar CM, Vyas KSK, Krishna YS. Clinical profile of dengue fever with severe thrombocytopenia and its complications: a retrospective study at a tertiary care hospital in South India. Int J Res Med Sci. 2017;5:1751-5.

Basak TB, Talukder SI. Clinical profile of dengue infection.Dinajpur Med Col. 2014;7(1):37-41.

Vibha V. Study of Haematological Profile of Dengue Fever and its Clinical Implication annals of applied biosciences. 2016;3:3.

Chairulfatah A, Setibudi D, Agnes R, Colebunder R. Thrombocytopenia and platelet transfusion in dengue. Hemorrhagic fever and dengue shock syndrome. WHO Dengue Bull. 2003;27:141-3.

Chansumrit A, Phimolthares V, Tartong P, Tapaneya-Olarn C, Tapaneya-Olarn W, Kowsathi P et al. Transfusion requirements in patients with Dengue hemorrhagic fever. Southeast Asian J Trop Med Public health. 2000;31(1):10-4.

Vishwanath M, Savitha MR, Krishnamurthy B. Platelet transfusion in dengue: peril or protection. Internat J Medic Res Rev. 2015;3:3.