Published: 2017-09-22

Study of serum Zinc status among type 2 diabetes mellitus patients

Ramesh Dasarathan, Senthil Kumar S., Ganesh V., Chenthil K. S.


Background: Both microvascular and macrovascular complications in diabetes are related to oxidative stress. Zinc which has antioxidant property, delays diabetic complications. The present study was conducted with the objective to study the relationship between serum Zinc level and HbA1C level in newly diagnosed type 2 diabetes mellitus and to compare serum Zinc level with its risk factors.

Methods: The present study was a cross sectional study, conducted on 100 patients attending the outpatient department at Rajiv Gandhi Government General Hospital and Madras Medical College, Chennai during the period from May 2015 to October 2015. Of them 50 were newly diagnosed type 2 diabetics and considered as diabetic group and other 50 were considered as controls, who attended the master health check-up. All patients were subjected to thorough general and systemic examination. Under strict aseptic precautions blood sample was collected from all the patients and the serum was investigated for creatinine, urea, zinc, HbA1c, cholesterol, triglycerides and fasting blood glucose. The data obtained were analysed using Microsoft excel software. Correlation was found out in SPSS by using regression equation.

Results: The body mass index (BMI) and mean systolic blood pressure (SBP) was significantly higher (p<0.001) in diabetic group as compared to controls. Serum levels of HbA1C and fasting blood glucose (FBG) levels were found to be significantly higher in diabetic group than in controls (p<0.001). Serum zinc levels were significantly higher in control group (p<0.001). Mean zinc value decreases with increase in HbA1c, FBG, BMI, SBP, DBP, triglycerides and cholesterol and the difference was statistically significant (p value <0.01). The relation between Pearson correlation coefficient for zinc and the above parameters were higher in diabetics than controls.

Conclusions: Lower serum zinc levels were found to be responsible for the development of macrovascular complications in type-2 diabetics. Hence there is a need for zinc supplementation in diabetic patients to prevent long term complications associated with it.


Complications, Serum zinc, Type 2 diabetes mellitus

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