Study of serum Zinc status among type 2 diabetes mellitus patients

Ramesh Dasarathan, Senthil Kumar S., Ganesh V., Chenthil K. S.


Background: Both microvascular and macrovascular complications in diabetes are related to oxidative stress. Zinc which has antioxidant property, delays diabetic complications. The present study was conducted with the objective to study the relationship between serum Zinc level and HbA1C level in newly diagnosed type 2 diabetes mellitus and to compare serum Zinc level with its risk factors.

Methods: The present study was a cross sectional study, conducted on 100 patients attending the outpatient department at Rajiv Gandhi Government General Hospital and Madras Medical College, Chennai during the period from May 2015 to October 2015. Of them 50 were newly diagnosed type 2 diabetics and considered as diabetic group and other 50 were considered as controls, who attended the master health check-up. All patients were subjected to thorough general and systemic examination. Under strict aseptic precautions blood sample was collected from all the patients and the serum was investigated for creatinine, urea, zinc, HbA1c, cholesterol, triglycerides and fasting blood glucose. The data obtained were analysed using Microsoft excel software. Correlation was found out in SPSS by using regression equation.

Results: The body mass index (BMI) and mean systolic blood pressure (SBP) was significantly higher (p<0.001) in diabetic group as compared to controls. Serum levels of HbA1C and fasting blood glucose (FBG) levels were found to be significantly higher in diabetic group than in controls (p<0.001). Serum zinc levels were significantly higher in control group (p<0.001). Mean zinc value decreases with increase in HbA1c, FBG, BMI, SBP, DBP, triglycerides and cholesterol and the difference was statistically significant (p value <0.01). The relation between Pearson correlation coefficient for zinc and the above parameters were higher in diabetics than controls.

Conclusions: Lower serum zinc levels were found to be responsible for the development of macrovascular complications in type-2 diabetics. Hence there is a need for zinc supplementation in diabetic patients to prevent long term complications associated with it.


Complications, Serum zinc, Type 2 diabetes mellitus

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Global report on diabetes - World Health Organization. Available at Accessed on 10 September 2015.

Saharia GK, Goswami RK. Evaluation of serum zinc status and glycated hemoglobin of type 2 diabetes mellitus patients in a tertiary care hospital of assam. J Lab Physicians. 2013;5(1):30-3.

Belete V, Dib R, Attah A. Zinc supplement for the prevention of type2 Diabetes mellitus. Cochrane database of systematic review. Nim Gov. 2007;1:CD 005525.

Chausmer AB. Zinc, insulin and diabetes. J Am CollNutr. 1998;17(2):109-15.

Mamza YP, Abdullahi ZB, Gali RM, Mshelia DS, Genesis RY, Habu SA. Status of serum zinc and magnesium among type 2 diabetic subjects in Maiduguri. IOSR-JDMS. 2016;15(7):66-70.

Thomas JP, Bachowski GJ, Girotti AW. Inhibition of cell membrane lipid peroxidation by cadmium- and zinc-metallothioneins. Biochim Biophys Acta. 1986;884:448-61.

Nathan DM, Singer DE, Hurxthal K, Goodson JD. The clinical information value of the glycosylated hemoglobin assay. N Engl J Med. 1984;310:341-6.

McNair P, Kiilerich S, Christiansen C, Christiansen M, Madsbad S, Transbol I. Hyperzincuria in insulin treated diabetes mellitus-its relation to glucose homeostasis and insulin administration. Clinica Chimica Acta. 1981;112:343-8.

Garg V, Gupta R, Goal R. Hypozincemia in diabetes mellitus. J Assoc Physicians India. 1994;42:720-1.

Williams NR, Rajput-Williams J, West J, Nigdikar S, Foote J, Howard A. Plasma, granulocyte and mononuclear cell copper and zinc in patients with diabetes mellitus. Analyst. 1995;120:887-90.

Tripathy S, Sumathi S, Bhupal Raj G. Minerals nutritional status of type 2 diabetic subjects. Int J Diabetes Dev Ctries. 2004;24:27-8.

Al-Maroof RA, Al-Sharbatti SS. Serum zinc levels in diabetic patients and effect of zinc supplementation on glycemic control of type 2 diabetics. Saudi Med J. 2006;27:344-50.

Mokdad AH, Bowman BA, Ford ES, Vinicor F, Marks JS, Koplan JP. The continuing epidemics of obesity and diabetes in the United States. JAMA. 2001;286:1195-200.

Seet RCS, Lee CYJ, Lim ECH, Quek AML, Huang H, Huang SH, et al. Oral zinc supplementation does not improve oxidative stress or vascular function in patients with type 2 diabetes with normal zinc levels. Atherosclerosis. 2011;219:231-9.

Al-Dohan JA, Haddad NS, Al-Rubaye H, Jawad MM. The relation between trace elements levels and some cardiovascular risk factors in patients with obstructive coronary artery disease in Basra. Biol Med. 2015;3:1-6.