Published: 2017-11-22

Clinical profile of patients with thrombocytopenia at tertiary health care centre

Sanjay V. Patne, Kailash N. Chintale


Background: In tropical countries like India thrombocytopenia is commonly encountered by clinicians in any speciality. Thrombocytopenia present as asymptomatic condition to sometimes becomes a life-threatening condition requiring blood transfusion in various etiological conditions. Infections like malaria and dengue are invariably associated to thrombocytopenia with changing trends in clinical features. Infection is the commonest cause of thrombocytopenia. The objective of study was to evaluate the different causes of thrombocytopenia along with study of clinical profile and laboratory parameters in patients with thrombocytopenia.

Methods: A cross-sectional hospital based study was conducted in Department of Medicine at Indian Institute of Medical Science and Research Medical College, Badnapur, Dist. Jalna, Maharashtra, India from November 2015 to August 2017. This study comprises cases of thrombocytopenia of age more than 12 years admitted with platelet count <1 lack/mm3 was included in study, whereas patients with malignancy and chemotherapy induced thrombocytopenia, idiopathic thrombocytopenic purpura, cirrhosis of liver were excluded.

Results: Study shows almost 55.83 % of total patients were below age of 30 years and 44.17% patients were above 30 years of age. The highest incidence of thrombocytopenia was seen in the age group of 21-30 years (32.50%) followed by 31-40 (25.83%) and 12-20 years (23.33%). The most common diseases that causes thrombocytopenia were infections (63.33%) [i.e. Dengue (30%), Malaria (20.83%), Enteric fever (5%), HIV (4.166%), Leptospirosis (1.66%) and DIC (1.66%)] and Megaloblastic anemia (21.66%) were common in younger population.

Conclusions: Study concluded that most common causes of thrombocytopenia were infections (63.33%) and megaloblastic anemia (21.66%). Bleeding manifestations were present in 37.50% of patients and the most common site of bleeding was skin and mucous membrane. The main etiological cause of bleeding in our study was dengue hemorrhagic fever followed by megaloblastic anaemia and malaria.



Bleeding manifestation, Infection, Thrombocytopenia, Splenomegaly

Full Text:



Konkle B. Disorders of platelets and vessel wall. In: Dan L Longo, Fauci AS, Hauser SL, Kasper DL, Jamson JL, Loscalzo J, Harrison’s Principles of Internal Medicine. 18th ed. New York, NY. 2012:1;965.

Konkle BA. Disorders of platelets and vessel wall. In: Fauci AS, Braunwald E, Kasper DL, et al, Harrison’s Principles of Internal Medicine. Vol. 1, 17th ed. New York, NY: McGraw-Hill;2008:718-23.

Murthy GL, Sahay RK, Srinivasan VR, Upadhaya AC, Shantaram V, Gayatri K. Clinical profile of falciparum malaria in a tertiary care hospital. J Ind Medic Assoc. 2000;98(4):160-2.

Levine SP. Miscellaneous causes of thrombocytopenia. Chapter-64. Wintrobe’s clinical hematology. 1999;10.

Stanworth SJ, Walsh TS, Prescott RJ, Lee RJ, Watson DM, Wyncoll DL. Thrombocytopenia and platelet transfusion in UK critical care: a multicenter observational study. Transfusion. 2013;53:1050-8.

Bizzaro N. EDTA‐dependent pseudothrombocytopenia: A clinical and epidemiological study of 112 cases, with 10‐year follow‐up. Ame J Hematol. 1995;50(2):103-9.

Liu S, Chai C, Wang C, Amer S, Lv H, He H, et al. Systematic review of severe fever with thrombocytopenia syndrome: virology, epidemiology, and clinical characteristics. Reviews Medic Virol. 2014;24(2):90-102.

Godhani UR, Devaliya JJ. Clinical Profile of Patients with Thrombocytopenia Attending a Tertiary Care, Hospital, Gujarat. Sch J App Med Sci. 2016;4(8E):3058-62.

Raikar SR, Kamdar PK, Dabhi AS. Clinical and Laboratory Evaluation of Patients with Fever with Thrombocytopenia: Ind J Clinic Pract. 2013;24(4):72-8.

Lohitashwa SB, Vishwanath BM, Srinivas G. Clinical and Lab Profile of Fever with Thrombocytopenia. Abstract Free Paper Oral Presentation-APICON, 2008. Available at:

Jadhav UM, Patkar VS, Kadam NN. Thrombocytopenia in malaria - correlation with type and severity of malaria. J Assoc. Physicians Ind. 2004;52:615-8.

Jayashree K, Manasa GC, Pallavi P, Manjunath GV. Evaluation of platelets as predictive parameters in dengue.Fever. Indian J Hematol Blood Transfus. 2011;27(3):127-30.

Lathia TB, Joshi R. Can hematological parameters discriminate malaria from nonmalarious acute febrile illness in the tropics? Ind J Med Sci. 2004;58(6):239-44.

Lee KH, Hui KP, Tan WC. Thrombocytopenia in sepsis: a predictor of mortality in the intensive care unit. Singapore Med J. 1993;34(3):245-6.

Shah HR, Vaghani BD, Gohel P, Virani BK. Clinical Profile Review of Patients with Thrombocytopenia: A Study of 100 Cases at a Tertiary Care Centre. Int J Cur Res Rev. 2015;7(6):82-7.

Lee GR, Foerster J, Lukens J, Paraskevas F, Greer JP, Rodgers GM. Shirley Parker Levine- Thrombocytopenia: Pathophysiology and Classification. In: Lipincott Wlliams and Wilkins,eds. Wintrobe’s Clinical Haematology. Vol. 2, 10th ed. Philadelphia;1999:1579-82.

Khan SJ, Abbass Y, Marwat MA. Thrombocytopenia as an indicator of malaria in adult population. Malar Res Treat. 2012;40(5):79-81.