DOI: http://dx.doi.org/10.18203/2349-3933.ijam20175082

Clinical profile of patients with thrombocytopenia at tertiary health care centre

Sanjay V. Patne, Kailash N. Chintale

Abstract


Background: In tropical countries like India thrombocytopenia is commonly encountered by clinicians in any speciality. Thrombocytopenia present as asymptomatic condition to sometimes becomes a life-threatening condition requiring blood transfusion in various etiological conditions. Infections like malaria and dengue are invariably associated to thrombocytopenia with changing trends in clinical features. Infection is the commonest cause of thrombocytopenia. The objective of study was to evaluate the different causes of thrombocytopenia along with study of clinical profile and laboratory parameters in patients with thrombocytopenia.

Methods: A cross-sectional hospital based study was conducted in Department of Medicine at Indian Institute of Medical Science and Research Medical College, Badnapur, Dist. Jalna, Maharashtra, India from November 2015 to August 2017. This study comprises cases of thrombocytopenia of age more than 12 years admitted with platelet count <1 lack/mm3 was included in study, whereas patients with malignancy and chemotherapy induced thrombocytopenia, idiopathic thrombocytopenic purpura, cirrhosis of liver were excluded.

Results: Study shows almost 55.83 % of total patients were below age of 30 years and 44.17% patients were above 30 years of age. The highest incidence of thrombocytopenia was seen in the age group of 21-30 years (32.50%) followed by 31-40 (25.83%) and 12-20 years (23.33%). The most common diseases that causes thrombocytopenia were infections (63.33%) [i.e. Dengue (30%), Malaria (20.83%), Enteric fever (5%), HIV (4.166%), Leptospirosis (1.66%) and DIC (1.66%)] and Megaloblastic anemia (21.66%) were common in younger population.

Conclusions: Study concluded that most common causes of thrombocytopenia were infections (63.33%) and megaloblastic anemia (21.66%). Bleeding manifestations were present in 37.50% of patients and the most common site of bleeding was skin and mucous membrane. The main etiological cause of bleeding in our study was dengue hemorrhagic fever followed by megaloblastic anaemia and malaria.

 


Keywords


Bleeding manifestation, Infection, Thrombocytopenia, Splenomegaly

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