DOI: http://dx.doi.org/10.18203/2349-3933.ijam20175519

Effect of surgical menopause on serum lipid profile-a prospective study

Renymol B., Ambili N. R., T. D. Unnikrishnan Kartha

Abstract


Background:Menopause marks the onset of cessation of ovarian function which is associated with changes in cardiovascular risk factors especially an unfavourable change in lipid profile. This is more pronounced is perimenopausal females who have undergone total hysterectomy with bilateral sapingo oopherectomy. This study aimed at looking into the changes occurring in the lipid profile and other cardiovascular risk in patients who have underwent oopherectomy over a 3 months period.

Methods: The study was conducted as a case control one. We studied 70 consecutive perimenopausal patients admitted in a tertiary care teaching medical college hospital in Kerala, South India who were admitted for hysterectomy and bilateral oopherectomy over a 1year period. The lipid profile and anthropometric measurement with blood pressure recording was done prior to surgery and the same patients were followed up after 3 months when the cardiovascular risk assessment and lipid profile estimation were repeated. Here, the cases acted as controls after the end of third month.

Results: It was found that after the end of 3 months of surgical menopause there was no significant change in body mass index, waist hip ratio or systolic BP. However, the DBP was higher in patients after surgery (78.68±7.94 vs 83.31±11.03, P <0.001). There was also statistically significant increase in total cholesterol (166.07±28.22 vs 242.94±45.65 [P<0.001]), TG (129.33±31.16 vs 177.06±50.57 P<0.001) and LDLc (107.83±20.06 vs 166.73±48.51 P>0.001). The HDLc was found to be 27% after 3 months of surgical menopause (59.31±8.22 vs 43.73±35 P>0.001.

Conclusions: Thus, it was concluded that there was a significant unfavourable effects on lipid profile and diastolic blood pressure 3 months after surgical menopause.


Keywords


Menopause, Surgical menopause, Lipid profile

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