Published: 2018-01-18

Effect of surgical menopause on serum lipid profile-a prospective study

Renymol B., Ambili N. R., T. D. Unnikrishnan Kartha


Background:Menopause marks the onset of cessation of ovarian function which is associated with changes in cardiovascular risk factors especially an unfavourable change in lipid profile. This is more pronounced is perimenopausal females who have undergone total hysterectomy with bilateral sapingo oopherectomy. This study aimed at looking into the changes occurring in the lipid profile and other cardiovascular risk in patients who have underwent oopherectomy over a 3 months period.

Methods: The study was conducted as a case control one. We studied 70 consecutive perimenopausal patients admitted in a tertiary care teaching medical college hospital in Kerala, South India who were admitted for hysterectomy and bilateral oopherectomy over a 1year period. The lipid profile and anthropometric measurement with blood pressure recording was done prior to surgery and the same patients were followed up after 3 months when the cardiovascular risk assessment and lipid profile estimation were repeated. Here, the cases acted as controls after the end of third month.

Results: It was found that after the end of 3 months of surgical menopause there was no significant change in body mass index, waist hip ratio or systolic BP. However, the DBP was higher in patients after surgery (78.68±7.94 vs 83.31±11.03, P <0.001). There was also statistically significant increase in total cholesterol (166.07±28.22 vs 242.94±45.65 [P<0.001]), TG (129.33±31.16 vs 177.06±50.57 P<0.001) and LDLc (107.83±20.06 vs 166.73±48.51 P>0.001). The HDLc was found to be 27% after 3 months of surgical menopause (59.31±8.22 vs 43.73±35 P>0.001.

Conclusions: Thus, it was concluded that there was a significant unfavourable effects on lipid profile and diastolic blood pressure 3 months after surgical menopause.


Menopause, Surgical menopause, Lipid profile

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Greendale GA, Lee NP, Arriola ER. The menopause. Lancet. 1999;353(9152):571-80.

Matthews KA, Meilahn E, Kuller LH, Kelsey SF, Caggiula AW, Wing RR. Menopause and risk factors for coronary heart disease. N Eng J Medic. 1989;321(10):641-6.

Shuster LT, Rhodes DJ, Gostout BS, Grossardt BR, Rocca WA. Premature menopause or early menopause: long-term health consequences. Maturitas. 2010;65(2):161-6.

Atsma F, Bartelink ML, Grobbee DE, van der Schouw YT. Postmenopausal status and early menopause as independent risk factors for cardiovascular disease: a meta-analysis. Menopause. 2006;13(2):265-79.

Rivera CM, Grossardt BR, Rhodes DJ, Brown Jr RD, Roger VL, Melton III LJ, et al. Increased cardiovascular mortality following early bilateral oophorectomy. Menopause (New York, NY). 2009;16(1):15.

Jacoby VL, Grady D, Wactawski-Wende J, Manson JE, Allison MA, Kuppermann M, et al. Oophorectomy vs ovarian conservation with hysterectomy: cardiovascular disease, hip fracture, and cancer in the Women's Health Initiative Observational Study. Archives Inter Medic. 2011;171(8):760-8.

Study TW. Design of the women’s health initiative clinical trial and observational study. Controlled clinical trials. 1998;19(1):61-109.

Thankappan KR, Valiathan MS. Country profile: India. Health at low cost--the Kerala model. Lancet. 1998;351(9111):1274-5.

Soman CR, Shahulhameed S, Ramankutty V, Vijayakumar K, Kunjukrishnapillai R, Ajayan K, et al. Cohort profile: the PROLIFE study in Kerala, India. Inter J Epidemiol. 2009;40(1):10-4.

Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. N Eng J Medic. 1999;340(23):1801-11.

Domenicode Aloysio, MarcoGambacciani, MicheleMeschia, FrancescoPansini, Alberto Bacchi Modena, PierFrancescoBolis et al. The effect of menopause on blood lipid and lipoprotein levels. Icarus Study Group: Atherosclerosis. 1999;147(1):147-53.

Belchetz PE. Hormonal treatment of postmenopausal women. N Eng J Medic. 1994;330(15):1062-71.