Importance of hematological and biochemical findings in alcoholics admitted to emergency department


  • Ramesh Gorghatta Hanumanthaiah Department of Accident and Emergency Medicine, BMCRI, Bangalore, Karnataka, India
  • Panchakshari Prasanna Bangalore Krishnap Department of Immunohematology and Transfusion Medicine, BMCRI, Bangalore, Karnataka, India
  • Dheemantha P. Department of Immunohematology and Transfusion Medicine, BMCRI, Bangalore, Karnataka, India
  • Sheerin Farhath Department of Emergency, Consultant Physician, Bangalore, Karnataka, India
  • Dayananda Biligi Department of Pathology, BMC and RI, Bangalore, Karnataka, India
  • Ranganath T. S. Department of Community Medicine, BMC and RI, Bangalore, Karnataka, India



Alcohol, Biochemical, Drinking patterns, Haematological, Parameters


Background: Alcoholism represents one of the most serious worldwide socioeconomic and health problems. An alcoholic is a person who consumes an amount of alcohol capable of producing pathological changes. The amount of alcohol capable of producing disease depends on a variety of factors, including genetic predisposition, malnutrition and concomitant viral infections of the liver. The association of heavy alcohol intake with a significant increase of all cause and non-cardiovascular mortality rates especially by cirrhosis, cancer and violent deaths.

Methods: This study was conducted on 500 patients who were taken from the emergency department over a period of one year, they were divided into two groups as none drinkers and heavy drinkers. 250 subjects were in each group. Frequency, quantity and type of alcohol were noted for each group. Patients presenting to emergency with known history of diabetes, anemia and hepatic encephalopathy were excluded.

Results: In our study there was no significant difference in the bio chemical tests of heavy drinkers and non-drinkers with respect to Glucose, sodium, potassium, chloride, Total Protein, albumin, globulin. But in current study significant difference in the values of GGT, ALT, AST and alkaline phosphatase (P>0.05) were noted among non-alcoholics and heavy drinkers.

Conclusions: Some of the Hematological parameters(MCV) and biochemical parameters like GGT, AST, ALT and alkaline phosphatase could be used for the diagnosis and treatment of alcoholism along with clinical examination if history about alcohol is missing.


Millwood IY, Lming L, Yumfongpeug. Alcohol consumption in 0.5 million people from 10 diverse region prevalence, patterns and socio-demographic and health related corelates: Internat J Epidemiol. 2013;42(3):816-27.

Barry KL, Frederic CB. Drinking over the life span: Alcohol Res. 2016;38(1):115-20.

Schuckit MA. Drug and Alcohol abuse: A clinical guide to diagnosis and treatment 5th edn. New York, plenum; 2000.

Mcintosh C, Chick J. Alcohol and the nervous system; J Neural Neurosurg Psychiatr. 2004; 75(Suppl 3);16-21.

Gyongyi S, Mandrekar P. Focus on: alcohol and the liver. Alcoholresp Health. 2010;3391-20;87-96.

Edoards GG, Roberto T, Vincenzo S. Liver enzyme alteration; a guide for clinicians. Canadian Med Assoc J. 2005;172(3);367-79.

Care T, Samuel WF and Valentian M. Diagnosis of alcoholic liver disease. World J Gastroenterol. 2014; 20(33):11684-99.

Oduola T, GAdeolum O, Oduola TA. Drinking patterns; Biochemical and Hematological findings in alcohol consumers in Ile-Ige Nigeria. Afr J Biotechnol. 2005;4(11)1304-8.

Conigrave KM, Degenhardt LJ, Whitefield JB. CCT, GGT and AST as markers of alcoholism. The WHO/ISBRA collaborative project. Alcohol. Clin. Epidemiol. 332-9.

Marway JS, Keating JW, Reeves J. Seromuscular and protein synthesis in various anatomical regions of the rat gastrointestinal tract and their response to acute ethanol toxicity. Eur J. Gastrointestinal. Hepatol. 1993;5;27-34.

Chandan KK, Saurabh B, Reetwik KD. Study of serum sodium and potassium level in patients with alcoholic liver disease attending Jorhat Medical College Hospital- A hospital based study. Inter J of Health Sciences and research. 2016;6(6):113-6.

Amitava D. Mean corpuscular volume and carbohydrate-Deficient transferrin as Alcohol Biomarkers. Alcohol and its Biomarkers. 2015;139-62.






Original Research Articles