Published: 2018-01-18

Retrospective study of white blood cell count and hematocrit in dengue fever

Denesh Narasimhan, Silpita Katragadda, M. Sathish


Background: Dengue is an extremely important tropical disease transmitted by the Aedes aegypti mosquito. Aim of the study: to study the white blood cell levels in serologically proven dengue cases; to study hematocrit levels in cases of dengue fever.

Methods: The present study is a retrospective observational analysis of white blood cell count (WBC count) and hematocrit in 235 serologically proven Dengue cases admitted in the years 2011-2012

Results: 107 cases (45.5%) had leukopenia, 111 cases (47.2%) had normal WBC counts and 12 cases had leukocytosis (5.1%).  23 cases had increased hematocrit (9.8%), 76 cases had a low hematocrit (32.3%) and 128 cases had a normal hematocrit (54.5%).

Conclusions: A significant proportion of patients had leukopenia which may be an early marker of dengue infection. Only a small percentage of patients had raised hematocrit. It may be that rise from baseline levels of haematocrit which may be more significant than absolute values.


Dengue fever, Leukopenia, Raised hematocrit

Full Text:



Dengue guidelines for diagnosis, treatment, prevention and control: new edition, Geneva. World Health Organization; 2009.

Dengue guidelines for diagnosis, treatment, prevention and control new edition. Geneva: World Health Organization. WHO. 2009:5.

Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control. World Health Organization. Geneva, WHO; 2009:10.

Ho TS, Wang SM, Lin YS, Liu CC. Clinical and laboratory predictive markers for acute dengue infection. J Biomed Sci. 2013;20(1):75.

Sawasdivorn S, Vibulvattanakit S, Sasavatpakdee M, Iamsirithavorn S. Efficacy of clinical diagnosis of dengue fever in paediatric age groups as determined by WHO case definition 1997 in Thailand. Dengue Bulletin 25:56-64.S.

Gregory CJ, Lorenzi OD, Colón L, García AS, Santiago LM, Rivera RC, et al. Utility of the tourniquet test and the white blood cell count to differentiate dengue among acute febrile illnesses in the emergency room. PLoS neglected tropical diseases. 2011;5(12):e1400.

Kalayanarooj S, Vaughn DW, Nimmannitya S, Green S, Suntayakorn S, Kunentrasai N, et al. Early clinical and laboratory indicators of acute dengue illness. J Infec Dis. 1997;176(2):313-21.

Shamsunder Khatroth. A Study on Clinical and Hematological Profile of Dengue Fever in a Tertiary Care Hospital. IAIM. 2017;4(8):96-102.

Azin FR, Gonçalves RP, Pitombeira MH, Lima DM, Castelo Branco I. Dengue: profile of hematological and biochemical dynamics. Revista brasileira de hematologia e hemoterapia. 2012;34(1):36-41.

Meena KC, Jelia S, Meena S, Arif M, Ajmera D, Jatav VS. A study of hematological profile in dengue fever at tertiary care center, Kota, Rajasthan, India. Int J Adv Med. 2016;3:621-4.