Clinical profile of adults with Guillain Barre Syndrome in North-West Rajasthan, India

Authors

  • Arvind Vyas S.P. Medical College and A.G. Hospitals, Bikaner, Rajasthan, India
  • Kartik Jaiswal S.P. Medical College and A.G. Hospitals, Bikaner, Rajasthan, India
  • Sarika Swami S.P. Medical College and A.G. Hospitals, Bikaner, Rajasthan, India
  • Madhu Sudan Rankawat S.P. Medical College and A.G. Hospitals, Bikaner, Rajasthan, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20162203

Keywords:

Guillain Barre Syndrome, Clinical profile, North-west Rajasthan

Abstract

Background: Guillain Barre Syndrome is a heterogenous symptom complex and an important cause of acute flaccid paralysis in children as well as adults. This study was conducted to see the clinical profile of adults admitted with Guillain Barre Syndrome.

Methods: This prospective study was conducted in the department of medicine and neurology of S. P. Medical College and A.G. Hospitals, Bikaner, Rajasthan, India. Clinical diagnosis of Guillain Barre Syndrome was based on proposed criteria. Clinical data of 30 such patients were analysed.

Results: In this part of India, Guillain Barre Syndrome is common in early decades and second peak is seen in 4th decade. Male to female ratio was 3.28:1. 70% patients were from rural area. Maximum number of cases came in month of May followed by April, March, July, 23.33%, 16.66%, 13.33%, 13.33% respectively. No patient came in January and October. Preceeding illness was present in 73.3% of cases. Neurological examination showed that 63.33% cases presented with quadriparesis, 50% had cranial nerve involvement, 36.6% cases had paraparesis only, 36.6% had autonomic instability.

Conclusions: In this part of Rajasthan, Guillain Barre Syndrome has bimodal occurrence with male preponderance. Commoner in rural population. March to July found common months of occurrence of disease. Most patients have antecedent illness and quadriparesis is commonest presentation.

References

Stephan L, Hauser, Asbury A. Guillain Barre syndrome and other immune mediated neuropathies. Harrison Principles Internal Med. 2005;2(16):2513-6.

Feasby TE. Axonal Guillain Barre Syndrome. Muscle Nerve. 1994;17(6):678-9.

Mckhann GM, Cornblath DR, Griffm JW, Ho Tw, Li CY, Jiang Z, Wu HS, Zhaori G, Liu Y, Jou LP. Acute motor axonal neuropathy: a frequent cause of acute flaccid paralysis in China. Ann Neurol. 1993;33:333-42.

Griffin JW, Li CY, Ho TW, Xue P, Macko C, Gao CY. Guillain Barre syndrome in Northern China: The spectrum of neuropathological changes in clinical defined cases. Brain. 1995;118:577-95.

Ho TW, Mishu B, Li CY, Gao CY, Cornblath DR, Griffin JW, et al. Guillain Barre syndrome in northern China. Relationship to Campylobacter, jejuni infection and anti-glycolipid antibodies. Brain. 1995;8:597-605.

Italian Guillain Barre Study Group. The prognosis and main prognostic indicators of Guillain Barre syndrome. Brain 1996; 119 : 2053-2061.

Giovannoi G, Hartung HP. The immune pathogenesis of multiple sclerosis and Guillain Barre syndrome. Curr Opin Neurol, 1996;9:165-77.

Winer JB, Hughes RAC, Osmond C. A prospective study of acute clinical idiopathic neuropathy. I Clinical features and their prognostic value. J Neurol Neurosurg Psychia. 1988;51:605-12.

Asbury AK, Cornblath DR. Assessment of current diagnostic criteria for Guillain Barre syndrome. Ann Neurol. 1990;27:521-24.

Ropper AH, Wijdicks EFM, Shahabi BT. Electrodiagnotic abnormalities in 113 consecutive patients with Guillain Barre syndrome. Arch Neurol. 1990;47:881-7.

Jiang W, Wang HD, Huang YG, Wan Q, Xu Y, Wu BR. Guillain Barre syndrome in northern China. Electromyogr Clin Neuroph'ysiol. 2001;41:387-91.

Rees JH, Thompson RD, Smeeton NC. Epidemiological study of Guiallain Bare syndrome in south east England. J Neurol Neurosurg Psychiatry. 1998;64:74-7.

Lyu RK, Tang LM. Guillain Barre syndrome in Taiwan: a clinical study of 167 patients. J Neurol Neurosurg Psychiatry. 1997;63:494-500.

Mckhann GM, Cornblath DR, Ho TW, Li CY, Bia AY, Wu HS. Clinical and electrophysiological aspect of acute paralytic diseases of children and young adults in Northern China. Lancet. 1991;338:593-7.

Sedano MJ, Challeja J. Guillain Barre syndrome is Cantabria, Spain an epidemiological and clinical study. Acta Neurol Scand. 1994;89(4):287-92.

Visser LH, Van Der, Meche FGA, Van DFA, Meulstee BC, Jacobs BC, Oomes PG. Guillain Barre syndrome without sensory loss (acute motor neuropathy): a subgroup with specific clinical electrodiagnostic and laboratory features. Brain. 1995;18:841-7.

Alessandro RD. Guillain Barre syndrome variants in Emillia Romagna, Italy, 1992-3: clinical features, and prognosis. Neurol Neurosurg Psychiatry. 1998;65:218-4.

Hung PL, Chang WN, Huang LT. A clinical and electro physiologic survey of childhood Guillain Barre Syndrome. Pediatric Neurology. 2004;30:86-91.

Loffel NB, Rossi LN, Mumenthaler M. The landry Guillain Barre syndrome: complications, prognosis, and natural history in 123 cases. J Neurol Sci. 1977;33:71-9.

Winer JB, Hughes RAC, Osmond C. A prospective study of acute clinical idiopathic neuropathy clinical features and their prognostic value. J neurol Neurosurg Psychiat. 1988;51:605-12.

Kaur U, Chopra JS, Prabhakar S. Guillain Barre syndrome a clinical electrophysiological and biochemical study. Acta Neurol Scand. 1986;73(4):394-402.

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Published

2016-12-29

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