Piperacillin/tazobactam induced toxic epidermal necrolysis and drug induced liver injury

Authors

  • Hardeep S. Deep Department of Medicine, SGRD Institute of Medical Sciences and Research, Amritsar, Punjab, India
  • Mohit Kumar Department of Medicine, SGRD Institute of Medical Sciences and Research, Amritsar, Punjab, India
  • Barjinder Pal Singh Department of Medicine, SGRD Institute of Medical Sciences and Research, Amritsar, Punjab, India
  • Nisha Kajla Department of Medicine, SGRD Institute of Medical Sciences and Research, Amritsar, Punjab, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20181091

Keywords:

DILI, Piperacillin, SJS, Steven Johnson syndrome, Tazobactam, TEN, Toxic epidermal necrolysis

Abstract

The liver and skin are the organs most commonly involved in serious adverse drug reactions. Rarely a drug reaction can affect both organs concurrently. The association of drug induced liver injury (DILI) and toxic epidermal necrolysis (TEN) is even rarer and may be rarely reported. This is a case report on development of both TEN and DILI following use of piperacillin / tazobactam. We describe our experience of DILI occurring in association with TEN including the etiological agent responsible, its clinical/ biochemical characteristics and ultimate outcome.

References

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Milir SM, Kelsy L, Neilendu K. Post-operative SJS secondary to piperacillin-tazobactam. IJLRI. 2013;4(6):36-20.

Neki NS, Singh SG, Amritpal S, Amanpreet K. Paracetamol induced Steven Johnson syndrome: toxic epidermal necrolysis overlap: the unusual suspect. Int J Med Health Res. 2016;12(2):59-61.

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Milir SM, Kelsy L, Neilendu K. Post-operative SJS secondary to piperacillin-tazobactam. IJLRI. 2013;4(6):36-20.

Eulalin P, Luisa I, Monica S. Paracetamol in therapeutic dosages and acute liver injury: Causality assessment in a prospective case series. BMC Gastroenterol. 2011;11(1):80.

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Published

2018-03-21

Issue

Section

Case Reports