Piperacillin/tazobactam induced toxic epidermal necrolysis and drug induced liver injury
DOI:
https://doi.org/10.18203/2349-3933.ijam20181091Keywords:
DILI, Piperacillin, SJS, Steven Johnson syndrome, Tazobactam, TEN, Toxic epidermal necrolysisAbstract
The liver and skin are the organs most commonly involved in serious adverse drug reactions. Rarely a drug reaction can affect both organs concurrently. The association of drug induced liver injury (DILI) and toxic epidermal necrolysis (TEN) is even rarer and may be rarely reported. This is a case report on development of both TEN and DILI following use of piperacillin / tazobactam. We describe our experience of DILI occurring in association with TEN including the etiological agent responsible, its clinical/ biochemical characteristics and ultimate outcome.
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