Study of lipid profile in cases of non-diabetic stroke

Ayaskanta Kar, Chinmayananda Dash, Malati Murmu, Karun Mahesh K. P.


Background: To study serum lipid profile in non-diabetic patients with stroke and to determine whether there is any significant correlation between them and to compare the serum lipid profile between ischaemic and haemorrhagic group. Design: Case control study.

Methods: The current study was done in the Department of Medicine VIMSAR, Burla, Odisha. Total 100 patients of completed stroke (Ischaemic63 and haemorrhagic37) and 30 controls were included in the study. All cases were adult (more than 14 years of age). Patients with suspected embolic stroke, diabetes (Type 1 and 2) and patients on lipid lowering drugs were excluded from the study. Routine investigations and fasting serum lipid profile was done.

Results: 45 patients had elevated serum total cholesterol levels out of which 75.56% had Ischaemic stroke and 24.49% had haemorrhagic stroke. 24 cases had elevated serum Triglyceride levels of which 66.67% had Ischaemic stroke and 29.17% had haemorrhagic stroke. 76.47% of cases having elevated serum LDL cholesterol suffered from Ischaemic stroke where as 20.59% had haemorrhagic stroke.

Conclusions: A statistically positive correlation was found between serum total cholesterol, Triglyceride, LDL levels and the risk of stroke.


Dyslipidemia, Lipid Profile, Stroke

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Smith WS, Johnston SC, Hemphill III JC. Cerebrovascular Diseases. In: Kasper DL, Hauser SL, Jameson JL, Fauci AS, Longo DL, Loscalzo J eds. Harrison’s Principle of Internal Medicine. 19th ed. McGraw Hill; 2015:2559-86.

Sreedhar K, Srikant B, Joshi L, Usha G. Lipid profile in non-diabetic stroke-a study of 100 cases. J Assoc Physicians India. 2010;58:547-51.

Futterman LG, Lemberg L. Stroke risk, cholesterol and statins. Am J Crit Care. 1999;8(6):416-9.

Demchuk AM, Hess DC, Brass LM, Yatsu FM. Is cholesterol a risk factor for stroke?: Yes. Arch Neurol. 1999;56(12):1518-20.

Ropper AH, Samuels MA, Klein JP. Cerebrovascular disease. Adam and Victor’s principle of Neurology. 10th ed. McGraw-Hill; 2014:780-2.

Grundy S, Becker D, Clark LT, Cooper RS, Denke MA, Howard J, et al. Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). Circulation-Hagertown. 2002;106(25):3143.

Jørgensen H, Nakayama H, Raaschou HO, Olsen TS. Stroke in patients with diabetes. The Copenhagen Stroke Study. Stroke. 1994;25(10):1977-84.

Gorelick PB, Mazzone T. Plasma lipids and stroke. J Cardiovasc Risk. 1999;(6):217-21.

Dayton S, Chapman JM, Pearce ML, Popjak GJ. Cholesterol, atherosclerosis, ischemic heart disease, and stroke. Ann Intern Med. 1970;72:97-109.

Konishi M, Iso H, Komachi Y, Iida M, Shimamoto T, Jacobs DR et al. Associations of serum total cholesterol, different types of stroke, and stenosis distribution of cerebral arteries. The Akita Pathology Study. Stroke. 1993;24(7):954-64.

Khan J, Rehman A. Comparison of clinical diagnosis with computed tomography in ascertaining type of stroke. J Ayub Med Coll Abbottabad. 2005;17(3):65-7.

Roquer J, Campello AR, Gomis M. Sex differences in first-ever acute stroke. Stroke. 2003;34(7):1581-5.

Benfante R, Yano K, Hwang LJ, Curb JD, Kagan A, Ross W. Elevated serum cholesterol is a risk factor for both coronary heart disease and thromboembolic stroke in Hawaiian Japanese men. Implications of shared risk. Stroke. 1994;25(4):814-20.

Dimascio R, Marchiolli R, Vituollo F, Dipasquale A, Cavasinni L, Tognoni G. Serum cholesterol and risk of ischemic stroke: results of a case-control study. Prev Med. 1995;24(2):128-33.

Iso H, Jacobs DR, Wentworth D, Neaton JD, Cohen JD, MRFIT Research Group. Serum cholesterol levels and six-year mortality from stroke in 350,977 men screened for the multiple risk factor intervention trial. N Engl J Med. 1989;320(14):904-10.

Harmsen P, Rosengren A, Tsipogianni A, Wilhelmsen L. Risk factors for stroke in middle-aged men in Göteborg, Sweden. Stroke. 1990;21(2):223-9.

Rastenyte D, Tuomilehto J, Domarkiene S, Cepaitis Z, Reklaitiene R. Risk factors for death from stroke in middle-aged Lithuanian men. Stroke. 1996;27(4):672-6.

Hart CL, Hole DJ, Smith GD. Risk factors and 20-year stroke mortality in men and women in the Renfrew/Paisley study in Scotland. Stroke. 1999;30(10):1999-2007.

Shahar E, Lloyd EC, Wayne DR, Lori LB, Christie MB, Paul GM, et al. The Atherosclerosis Risk in Communities (ARIC) Study. Stroke. 2003;34:623-7.

Hachinski V, Graffagnino C, Beaudry M, Bernier G, Buck C, Donner A, et al. Lipids and stroke: a paradox resolved. Arch Neurol. 1996;53(4):303-8.

Sridharan R. Risk factors for ischemic stroke: a case control analysis. Neuroepidemiol. 1992;11(1):24-30.

Pedro-Botet J, Senti M, Nogues X, Rubiés-Prat J, Roquer J, D'olhaberriague L, et al. Lipoprotein and apolipoprotein profile in men with ischemic stroke. Role of lipoprotein (a), triglyceride-rich lipoproteins, and apolipoprotein E polymorphism. Stroke. 1992;23(11):1556-62.

Simons LA, McCallum J, Friedlander Y, Simons J. Risk factors for ischemic stroke. Stroke. 1998;29(7):1341-6.

Sacco RL, Benson RT, Kargman DE, Boden-Albala B, Tuck C, Lin IF, et al. High-density lipoprotein cholesterol and ischemic stroke in the elderly: the Northern Manhattan Stroke Study. JAMA. 2001;285(21):2729-35.