Prospective study of blood lipid parameters in patients with type-2 diabetes mellitus and its correlation with the glycated hemoglobin
Keywords:Lipid parameters, Type 2 diabetes mellitus, HbA1c
Background: Patients with type 2 diabetes mellitus (T2DM) are accompanied (many a time ignored) by dyslipidemia; such patients are the easy targets for the development of cardiovascular disease (CVD). An early treatment to normalize abnormal lipid levels can reduce the CVD and related mortality. The aim was to measure blood lipid parameters in patients with T2DM and their relation with the glycemic control.
Methods: Prospective study including 124 T2DM patients in the Department of Medicine, Mayo Institute of Medical sciences, Barabanki, Uttar Pradesh, India between January 2016 to June 2016. Brief history, examination and investigations including fasting plasma glucose (FPG), post prandial blood glucose (PPG), glycated hemoglobin (HbA1c), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) were done. Correlation was obtained for lipid parameters between patients having HbA1c <7% and HbA1c ≥7%.
Results: Male predominance (57.25%) was recorded in present study. Mean age of study population was 52.81±10.77 years and most of them belong to age group of 56-65 years (30.64%). Mean height, weight, diabetes duration and BMI were 1.56±0.21 meters, 72.13±13.94 kgs, 5.22±2.71 years and 30.13±4.58 kg/m2respectively. Insignificant difference was obtained between mean TC, HDL-C, TG, LDL-C, TC/HDL, LDL/HDL, VLDL-C and non HDL-C in patients with HbA1c <7% (151.86±54.80 mg/dl, 46.0±22.26 mg/dl, 118.59±84.59 mg/dl, 154.86±120.36 mg/dl, 7.0±14.78, 2.05±0.84, 37.27±25.41 mg/dl and 114.24±47.12 mg/dl respectively) when compared with patients with HbA1c ≥7% (169.20±44.72 mg/dl, 40.66±10.97 mg/dl, 154.75±123.22 mg/dl, 193.11±148.94 mg/dl, 9.25±49.58, 2.42±0.93, 50.97±30.86 mg/dl and 128.40±42.12 mg/dl respectively) (p>0.05). A significant positive correlation was obtained between HbA1c and TC (r=0.216, p=0.016), TG (r=0.269, p=0.003), LDL/HDL ratio (r=0.296, p=0.001), VLDL-C (r=0.235, p=0.009) and non HDL-C (r=0.250, p=0.007) whereas a negative correlation was obtained with HDL-C (r= -0.192, p=0.032). In present study, 21.77% had hypercholesterolemia, 54.83% had low HDL-C level, 32.25% had hypertriglyceridemia and 72.58% patients had high LDL-C level.
Conclusions: Type 2 DM is associated with dyslipidemia and both together are the major risk factors for development of cardiovascular disease. There was a positive correlation between HbA1c and abnormal lipid parameters in patients with T2DM.
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