Prospective study of blood lipid parameters in patients with type-2 diabetes mellitus and its correlation with the glycated hemoglobin

Kumar Prafull Chandra, Dhirendra Kumar Shukla


Background: Patients with type 2 diabetes mellitus (T2DM) are accompanied (many a time ignored) by dyslipidemia; such patients are the easy targets for the development of cardiovascular disease (CVD). An early treatment to normalize abnormal lipid levels can reduce the CVD and related mortality. The aim was to measure blood lipid parameters in patients with T2DM and their relation with the glycemic control.

Methods: Prospective study including 124 T2DM patients in the Department of Medicine, Mayo Institute of Medical sciences, Barabanki, Uttar Pradesh, India between January 2016 to June 2016. Brief history, examination and investigations including fasting plasma glucose (FPG), post prandial blood glucose (PPG), glycated hemoglobin (HbA1c), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) were done. Correlation was obtained for lipid parameters between patients having HbA1c <7% and HbA1c ≥7%.

Results: Male predominance (57.25%) was recorded in present study. Mean age of study population was 52.81±10.77 years and most of them belong to age group of 56-65 years (30.64%). Mean height, weight, diabetes duration and BMI were 1.56±0.21 meters, 72.13±13.94 kgs, 5.22±2.71 years and 30.13±4.58 kg/m2respectively. Insignificant difference was obtained between mean TC, HDL-C, TG, LDL-C, TC/HDL, LDL/HDL, VLDL-C and non HDL-C in patients with HbA1c <7% (151.86±54.80 mg/dl, 46.0±22.26 mg/dl, 118.59±84.59 mg/dl, 154.86±120.36 mg/dl, 7.0±14.78, 2.05±0.84, 37.27±25.41 mg/dl and 114.24±47.12 mg/dl respectively) when compared with patients with HbA1c ≥7% (169.20±44.72 mg/dl, 40.66±10.97 mg/dl, 154.75±123.22 mg/dl, 193.11±148.94 mg/dl, 9.25±49.58, 2.42±0.93, 50.97±30.86 mg/dl and 128.40±42.12 mg/dl respectively) (p>0.05). A significant positive correlation was obtained between HbA1c and TC (r=0.216, p=0.016), TG (r=0.269, p=0.003), LDL/HDL ratio (r=0.296, p=0.001), VLDL-C (r=0.235, p=0.009) and non HDL-C (r=0.250, p=0.007) whereas a negative correlation was obtained with HDL-C (r= -0.192, p=0.032). In present study, 21.77% had hypercholesterolemia, 54.83% had low HDL-C level, 32.25% had hypertriglyceridemia and 72.58% patients had high LDL-C level.

Conclusions: Type 2 DM is associated with dyslipidemia and both together are the major risk factors for development of cardiovascular disease. There was a positive correlation between HbA1c and abnormal lipid parameters in patients with T2DM.  


Lipid parameters, Type 2 diabetes mellitus, HbA1c

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Samatha P, Prabodh VS, Chowdary NVS, Shekhar R. Glycated hemoglobin and serum lipid profile associations in type 2 diabetes mellitus patients. J Pharmac Biomed Sci. 2012;17(17):1-4.

Mooradian AD. Dyslipidemia in type 2 diabetes mellitus. Nature Clin Pract Endocrinol Metabol. 2009;5(3):150-9.

Ayaz KM, Ravindra M, Vivek R, Joshi P, Bhat G. A study on APO B100/APO A-I Ratio in uncontrolled type 2 diabetes mellitus. Int J Appl Biol Pharma Tech. 2011;2(1):379-84.

Nikitov Z, Iliev R, Miteva P, Koeva K, Gerenova J. Parameters of lipid metabolism and their relations with glycemic control in type 2 diabetic patients. Trakia J Sci. 2014;12(1):181-3.

Singh G, Kumar A. Relationship among HbA1c and lipid profile in Punjabi type 2 diabetic population. J Exercise Sci Physiotherapy. 2011;7(2):99-102.

Goldberg IJ. Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis. J Lipid Res. 1996;37:693-707.

Meenu J, Jayendrasinh MJ, Neeta M. Correlation between HbA1c values and lipid profile in type 2 diabetes mellitus. Int J Basic App Physiology. 2013;2(1):47-50.

Khan HA. Association between glycaemic control and serum lipids profile in type 2 diabetic patients: HbA1c predicts dyslipidaemia. Clin Exp Med. 2007;7:24-9.

Mahato RV, Gyawali P, Raut PP, Regmi P, Singh KP, Pandeya DR et al. Association between glycaemic control and serum lipid profile in type 2 diabetic patients: Glycated haemoglobin as a dual biomarker. Biomed Res. 2011;22(3):375-80.

Rohlfing CL, Wiedmeyer HM, Little RR, England JD, Tennill A, Goldstein DE. Defining the relationship between plasma glucose and HbA1c: analysis of glucose profiles and HbA1c in the Diabetes Control and Com-plications trial. Diab Care. 2002;25:275-8.

Selvin E, Wattanakit K, Steffes MW, Coresh J, Sharrett AR. HbA1c and peripheral arterial disease in diabetes: the atherosclerosis risk in communities study. Diabetes Care. 2006;29:877-82.

Khaw KT, Wareham N, Luben R, Bingham S, Oakes S, Welch A. Glycated haemoglobin, diabetes, and mortality in men in norfolk cohort of European prospective investigation of cancer and nutrition. Br Med J. 2001;322:15-8.