Analysis of the effect of sodium valproate sustained release tablets on epilepsy control and cognitive improvement in elderly patients

Guixing Xu, Fang Xiao, Hua Liu, Donghua Zheng


Background: To study the effect of sodium valproate sustained release tablets on epilepsy control and cognitive function improvement in elderly patients.

Methods: Study was conducted from January 2018 to December 2019, the elderly epilepsy patients admitted in our center were prospectively collected and divided into experimental group and control group according to the method of random number table. The experimental group was treated with sodium valproate sustained-release tablets, and the control group was treated with carbamazepine tablets. The epilepsy control rate and cognitive function improvement of the two groups were observed.

Results: total of 71 patients entered the study, including 36 in the experimental group and 35 in the control group; the epilepsy control rate (p = 0.03) and the improvement of cognitive function (p = 0.01) in the experimental group were better than those in the control group.

Conclusions: Sodium valproate sustained-release tablets can improve the epilepsy control rate and cognitive function of elderly epilepsy patients, but it needs further large samples and external data validation.


Cognition, Elderly, Epilepsy, Improvement, Sodium valproate sustained release tablets

Full Text:



Manford M. Recent advances in epilepsy. J neurol. 2017;264(8):1811-24.

Scheffer IE, French J, Hirsch E, Jain S, Mathern GW, Moshé SL, et al. Classification of the epilepsies: new concepts for discussion and debate—special report of the ILAE Classification Task Force of the Commission for Classification and Terminology. Epilepsia Open. 2016 Sep;1(1-2):37-44.

Chen LA, Cheng SJ, Jou SB. Epilepsy in the Elderly. Inter J Gerontol. 2012 Jun 1;6(2):63-7.

Szaflarski JP, Kay B, Gotman J, Privitera MD, Holland SK. The relationship between the localization of the generalized spike and wave discharge generators and the response to valproate. Epilepsia. 2013 Mar;54(3):471-80.

Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005–2009. Epilepsia. 2010 Apr;51(4):676-85.

Chen LA, Cheng SJ, Jou SB. Epilepsy in the Elderly. Inter J Gerontol. 2012 Jun 1;6(2):63-7.

Bergey G, Birnbaum AK, Caserta FM, Ferrendelli JA, French JA, et al. Diagnosis and treatment selection in elderly patients with epilepsy. Adv Stud Med. 2006;6(3C):S195-209.

Stephen LJ, Kelly K, Mohanraj R, Brodie MJ. Pharmacological outcomes in older people with newly diagnosed epilepsy. Epilep Behavior. 2006 Mar 1;8(2):434-7.

Pohlmann-Eden B, Marson AG, Noack-Rink M, Ramirez F, Tofighy A, Werhahn KJ, et al. Comparative effectiveness of levetiracetam, valproate and carbamazepine among elderly patients with newly diagnosed epilepsy: subgroup analysis of the randomized, unblinded KOMET study. BMC Neurol. 2016 Dec;16(1):149.

Sillanpää M, Lastunen S, Helenius H, Schmidt D. Regional differences and secular trends in the incidence of epilepsy in Finland: a nationwide 23‐year registry study. Epilepsia. 2011 Oct;52(10):1857-67.

Malamiri RA, Ghaempanah M, Khosroshahi N, Nikkhah A, Bavarian B, Ashrafi MR. Efficacy and safety of intravenous sodium valproate versus phenobarbital in controlling convulsive status epilepticus and acute prolonged convulsive seizures in children: a randomised trial. European J Paediatr Neurol. 2012 Sep 1;16(5):536-41.

Su Y, Liu G, Tian F, Ren G, Jiang M, Chun B, et al. Phenobarbital versus valproate for generalized convulsive status epilepticus in adults: a prospective randomized controlled trial in China. CNS drugs. 2016 Dec 1;30(12):1201-7.

Motika PV, Spencer DC. Treatment of Epilepsy in the Elderly. Current Neurol Neurosci Reports. 2016;16(11):96.

Rowan AJ, Ramsay RE, Collins JF, Pryor F, Boardman KD, Uthman BM, et al. New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. Neurol. 2005 Jun 14;64(11):1868-73.

Saetre E, Abdelnoor M, Perucca E, Taubøll E, Isojärvi J, Gjerstad L. Antiepileptic drugs and quality of life in the elderly: results from a randomized double-blind trial of carbamazepine and lamotrigine in patients with onset of epilepsy in old age. Epilep Behavior. 2010 Mar 1;17(3):395-401.