Gut microbiota: changing the disease architecture
DOI:
https://doi.org/10.18203/2349-3933.ijam20202077Abstract
Gut microflora comprising of trillions of various bacteria, protozoan, virus and fungi who live as a super-complex ecosystem in human body mostly (around 70%) in gastrointestinal tract. In habitating skin, mouth, intestine and sexual organs they live as symbiotic, commensal or pathogenic organism in the human body. These gut microflora interplay with bodily metabolic, immune, endocrinal and nervous system which leads to various pathophysiological mechanism for the causation of related disorders. This altered ‘Brain gut axis’ is responsible for disorders like anxiety, depression, autism, schizoaffective or bipolar disorder and also diseases like Parkinson’s disease and multiple sclerosis.1
References
Ghosh A, Bandyopadhyay D, Nanda P, Mahapatra SC. Microbes-Gut-Brain Axis: A Possible Future Therapeutics Target for Gastrointestinal and Behavioural Disorder. Int J Health Sci Res. 2015;5(1):321-29.
Galley JD, Bailey MT. Impact of stressor exposure on the interplay between commensal microbiota and host inflammation. Gut Microbes. 2014;5(3):390-6.
Mayer EA. Gut feelings: the emerging biology of gut–brain communication. Nature Reviews. Neuroscience. 2011;12(8):453-66.
Smith, Andrey P. The tantalizing links between gut microbes and the brain. Nature. 2015;526:312-4.
Mangiola F, Ianiro G, Franceschi F, Fagiuoli S, Gasbarrini G, Gasbarrini A. Gut microbiota in autism and mood disorders. World J Gastroenterol. 2016;221(1):361.
Chen J, Chia N, Kalari KR, Yao JZ, Novotna M, Soldan MM, et al. Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls. Sci Rep. 2016;6(1):1-10.
Mulak A, Bonaz B. Brain-gut-microbiota axis in Parkinson’s disease. World J Gastroenterol. 2015;21:10609-20.
Parmar A. Gut-brain axis, psychobiotics and mental health. Asian J Psychiatr. 2016;22:84-5.
