Rare side effect of a common drug
Keywords:Metronidazole induced neurotoxicity, MRI, Dentate nuclei, Corpus callosum
Metronidazole is most commonly used antimicrobial agent to treat various anaerobic bacterial and parasitic infections. Metronidazole induced side-effects are usually mild but neurotoxicity associated with it is rare. Here we report 33 year old para 1 living 1 (P1L1) post lower segment cesarean section (LSCS) discharged with metronidazole for 14 days presented to us with signs and symptoms of neurotoxicity with magnetic resonance imaging (MRI) brain findings consistent to metronidazole toxicity.
Kuriyama A, Jackson JL, Doi A, Kamiya T. Metronidazole-induced central nervous system toxicity: a systematic review. Clinical neuropharmacol. 2011;34(6):241-7.
Kalia V, Vibhuti KS. Case report: MRI of the brain in metronidazole toxicity. The Indian journal of radiology & imaging. 2010;20(3):195.
Patel L, Batchala P, Almardawi R, Morales R, Raghavan P. Acute metronidazole-induced neurotoxicity: an update on MRI findings. Clin Radiol. 2020;75(3):202-8.
Li L, Tang X, Li W, Liang S, Zhu Q, Wu M. A case of methylprednisolone treatment for metronidazole-induced encephalopathy. BMC neurol. 2019;19(1):49.
Roy U, Panwar A, Pandit A, Das SK, Joshi B. Clinical and neuroradiological spectrum of metronidazole induced encephalopathy: our experience and the review of literature. Journal of clinical and diagnostic research: JCDR. 2016;10(6):OE01.
Chandak S, Agarwal A, Shukla A, Joon P. A case report of metronidazole induced neurotoxicity in liver abscess patient and the usefulness of MRI for its diagnosis. Journal of clinical and diagnostic research: JCDR. 2016;10(1):TD06.
Agarwal A, Kanekar S, Sabat S, Thamburaj K. Metronidazole-induced cerebellar toxicity. Neurology international. 2016;8(1).