DOI: http://dx.doi.org/10.18203/2349-3933.ijam20210101

Association of serum amylase and lipase levels in newly diagnosed type 2 diabetes mellitus

Hareesh R., Harish K. V., Akshatha Savith

Abstract


Background: Type 2 diabetes mellitus is a chronic metabolic disorder due to insulin resistance caused by destruction of beta cells of pancreas. Insulin resistance in newly diagnosed type 2 diabetes mellitus patients leads to hyperglycemia. Serum amylase and lipase levels is an exocrine enzyme produced by acinar cells of pancreas. Altered levels of serum amylase and lipase leads to endocrine disorders, metabolic syndrome and diabetes mellitus.

Methods: This is a case-control study conducted in Akash Institute of Medical Sciences, A total 100 subjects (50 cases and 50 controls). All the subjects included after informed consent, blood samples are collected from the all the subjects. The serum amylase and was estimated by using enzymatic commercial available kits and fasting blood sugar (FBS), post-parandial blood sugar (PPBS), renal function test (RFT) and liver function test (LFT) was also estimated by laboratory standard methods.

Results: This study evaluated the FBS, PPBS, RFT, LFT, Amylase and Lipase levels in patients with newly diagnosed type 2 diabetes mellitus patients and compare them with healthy controls. The serum amylase and lipase levels more significantly elevated in newly diagnosed type 2 diabetes mellitus patients and compared with the healthy controls. The study also found that significantly elevated levels of FBS, PPBS, RFT and LFT in newly diagnosed type 2 diabetes mellitus patients and compared with the healthy controls, The statistically significant levels of serum amylase and lipase levels in patients with newly diagnosed type 2 diabetes mellitus when compared with the controls (p=0.0001).

Conclusions: The study suggesting that to estimation of serum amylase and lipase levels in newly diagnosed type 2 diabetes mellitus patients useful for early detection of diabetes mellitus and its complications. Because elevated levels of serum amylase and lipase in patients with newly diagnosed type 2 diabetes mellitus, these levels are positively correlated with the FBS and PPBS.  


Keywords


T2DM, Amylase, Lipase, ADA

Full Text:

PDF

References


Henderson JR, Daniel PM, Fraser PA. The pancreas as a single organ: the influence of the endocrine upon the exocrine part of the gland. Gut. 1981;22:158-67.

Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27(3):1047-53.

Ewald N, Hardt PD. Diagnosis and treatment of diabetes mellitus in chronic pancreatitis. World J Gastroenterol. 2013;19(42):7276-81.

Yegneswaran B, Pitchumoni CS. When should serum amylase and lipase levels be repeated in a patient with acute pancreatitis?. Cleve Clin J Med. 2010;77:230-231.

Skrha J, Stĕpán J. Clinical significance of amylase isoenzyme determination. Acta Univ Carol Med Monogr. 1987;120:1-81.

Aughsteen AA, Abu-Umair MS, Mahmoud SA. Biochemical analysis of serum pancreatic amylase and lipase enzymes in patients with type 1 and type 2 diabetes mellitus. Saudi Med J. 2005;26:73-77.

Kaur A, N Verma. Proteomics: A hallmark tool for identification of biomarker (LIPASE) in type I & II diabetes mellitus patients. Adv Appl Sci Res. 2012;3(3):1842-847.

Ewald N, PD Hardt. Diagnosis and treatment of diabetes mellitus in chronic pancreatitis. World J Gastroenterol. 2013;19(42):7276-281.

Gonzales-Perez A, Schlienger RG, Rodriguez LA. Acute pancreatitis in association with type 2 diabetes and antidiabetic drugs. Diabetes Care. 2010;33(12):2580-585.

American Diabetes Association. Standards of medical care in diabetes 2018. Diabates Care. 2018;36(1):S11-S66.

Gonzales-Perez A, Schlienger RG, Rodriguez LA. Acute pancreatitis in association with type 2 diabetes and antidiabetic drugs. Diabetes Care. 2010;33(12):580-2585.

Noel RA, Braun DK, Patterson RE. Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: a retrospective cohort study. Diabetes Care. 2009;32:834-38.

Chiolero A, Faeh D, Paccaud F, Cornuz J. Consequences of smoking for body weight, body fat distribution, and insulin resistance. Am J Clin Nutr. 2008;87:801-09.

The committee of Japan Diabetes Society on the diagnostic criteria of diabetes mellitus: Report of the Committee on the classification and diagnostic criteria of diabetes mellitus. J Jpn Diabetes Soc. 2010;53:450-67.

The committee of Japan Diabetes Society on the diagnostic criteria of diabetes mellitus: Report of the Committee on the classification and diagnostic criteria of diabetes mellitus. J Jpn Diabetes Soc. 2010;53:450-67.

Wang YM, Zhao LH, Su JB, Qiao HF, Wang XH, Xu F, et al. Glycemic variability in normal glucose tolerance women with the previous gestational diabetes mellitus. Diabetol Metab Syndr. 2015;7:82.

Nathan DM, Turgeon H, Regan S. Relationship between glycated haemoglobin levels and mean glucose levels over time. Diabetologia. 2007;50:2239-244.

DeVries JH, Bain SC, Rodbard HW. Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1C targets. Diabetes Care. 2012;35:1446-454.

Lando HM, Alattar M, Dua AP. Elevated amylase and lipase levels in patients using glucagonlike peptide-1 receptor agonists or dipeptidyl-peptidase-4 inhibitors in the outpatient setting. Endocr Pract. 2012;18:472-77.

Bastyr EJ, Barkin J, Botros FT. High incidence of elevated lipase and amylase in type 2 diabetes patients (T2DM) (abstract). Pancreas. 2009;38:980.

Rakhee Y, Prakash JB, Kumar SV, Kumar MN. The Evaluation of Serum Amylase in the Patients of Type 2 Diabetes Mellitus, with a Possible Correlation with the Pancreatic Functions. Journal of Clinical and Diagnostic Research. 2013;7(7):1291-294.

Vantyghem MC, Haye S, Balduyck M, Hober C, Degand PM, Lefevre J. Changes in serum amylase, lipase and leukocyte elastase during diabetic ketoacidosis and poorly controlled diabetes. Acta Diabetologica. 1999;36(1-2):39-44.

Aughsteen AA, Mohammed Fl. Insulin enhances amyase and lipase activity in the pancreas of strptozocin-diabetic rats. An in vivo study. Saudi Med J. 2002;23(7):838-44.

Srihardyastutie A, Soeatmadji DW, Fatchiyah, Aulanni A. Relation of Elevated Serum Lipase to Indonesian Type 2 Diabetes Mellitus Progression. Biomedical Research. 2015;26(2):293-98.

Steinberg WM, DeVries JH, Wadden TA. Longitudinal monitoring of lipase and amylase in adults with type 2 diabetes and obesity: evidence from two phase 3 randomized clinical trials with once

daily GLP-1 analog liraglutide. Gastroenterol. 2012;142(1):S850-851.