Lytic lesions of bone: a cytological and histopathological correlative study


  • Aria Jyothi A. Department of Pathology, Government, T. D. Medical College, Alappuzha, Kerala
  • Lilarani Vijayaraghavan Department of Pathology, Government Medical College, Thiruvananthapuram, Kerala, India



Lytic lesions of bone, Fine needle aspiration cytology, Histopathological diagnosis


Background: Lytic lesions of bone are easier to aspirate and fine needle aspiration cytology aids in an earlier diagnosis. The findings are correlated with radiological findings and subsequent histopathological diagnosis. Sensitivity, specificity, positive and negative predictive value of fine needle aspiration cytology of lytic lesions of bone evaluated.

Methods: It was a descriptive study for 2 years. All types of lytic lesions of bone were aspirated with fine needle along with radiological assistance. The cytological diagnosis was correlated with histo pathological diagnosis.

Results: A total number of 84 cases were studied with histopathological follow up in 51 cases. FNAC diagnosis was correct in 34 cases. In 8 cases, cytology diagnosis was malignant neoplasm, but correct typing was not possible. In 9 cases cytological diagnosis were inconclusive due to inadequate material. Sensitivity of the test was 70.83%, specificity was 50.12%, positive predictive value was 97.14%, negative predictive value was 6.67% and overall accuracy was 70 .01%.

Conclusions: The role of FNAC in diagnosis of bone lesions is both promising and challenging. Because of simplicity, low morbidity and economical benefits, FNAC should be the first step in the diagnosis of bone lesions.


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