Published: 2021-03-23

Cryptoccal meningitis in non-HIV, non-organ transplant diabetic patients

Sneha Biradar, Balakrishna Teli


Cryptococcosis is an important opportunistic fungal infection and also cause of death due to central nervous system disease among patients with human immunodeficiency virus worldwide. Most of the cases occur in immunocompromised patients like HIV infected people, people with organ transplants and on immunosuppressants. Nowdays there is increase in cases of cryptoccal meningitis among diabetic patients. Current case series includes cryptococcal meningitis among diabetic patients after ruling out of other immunocompromised states.



Cryptoccal meningitis, Diabetic patients, HIV, Organ transplant

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Park BJ, Wannemuehler KA, Marston BJ. Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS. 2009;23(4):525-30.

Pappas PG, Perfect JR, Cloud GA. Cryptococcosis in human immunodeficiency virus-negative patients in the era of effective azole therapy. Clin Infect Dis. 2001;33(5):690-9.

Manorenj S, Rani VL, Suravaram S, Reddy CS. Cryptococcus neoformans meningitis in a non-HIV infected, nonorgan transplant, immunocompromised individual. Arch Med Health Sci. 2018;6:139-42.

Kiertiburanakul S, Wirojtananugoon S, Pracharktam R, Sungkanuparph S. Cryptococcosis in human immunodeficiency virus negative patients. Int J Infect Dis. 2006;10:72-8.

Casqueiro J, Alves C. Infections in patients with diabetes mellitus: A review of pathogenesis. Indian J Endocrinol Metab. 2012;16(1):S27-36.

Geerlings SE, Hoepelman AI. Immune dysfunction in patients with diabetes mellitus (DM). Immunol Med Microbiol. 1999;26:259-65.

Stoeckle M, Kaech C, Trampuz A, Zimmerli W. The role of diabetes mellitus in patients with bloodstream infections. Swiss Med Wkly. 2008;138:512-9.

Pappas PG. Therapy of cryptococcal meningitis in non HIV infected patients. Curr Infect Dis Rep. 2001; 3:365-70.

Byrnes EJ, Bartlett KH, Perfect JR, Heitman J. Cryptococcus gattii: An emerging fungal pathogen infecting humans and animals. Microbes Infect. 2011; 13:895-907.

Mitchell DH, Sorrell TC, Allworth AM, Heath CH, McGregor AR, Papanaoum K, et al. Cryptococcal disease of the CNS in immunocompetent hosts: Influence of cryptococcal variety on clinical manifestations and outcome. Clin Infect Dis. 1995; 20:611-6.

Peleg AY, Weerarathna T, McCarthy JS, Davis TM. Common infections in diabetes: Pathogenesis, management and relationship to glycaemic control. Diabetes Metab Res Rev. 2007;23:3-13.