Correlations between level of vitamin D serum and disease severity COVID-19

Authors

  • I. Gede Ketut Sajinadiyasa Department of Internal Medicine, Faculty of Medicine Udayana University/ Prof. Dr. I. G. N. G. Ngoerah General Hospital, Denpasar, Bali, Indonesia
  • Ketut Suega Department of Internal Medicine, Faculty of Medicine Udayana University/ Prof. Dr. I. G. N. G. Ngoerah General Hospital, Denpasar, Bali, Indonesia
  • Nova Andari K. Department of Internal Medicine, Faculty of Medicine Udayana University/ Prof. Dr. I. G. N. G. Ngoerah General Hospital, Denpasar, Bali, Indonesia

DOI:

https://doi.org/10.18203/2349-3933.ijam20242306

Keywords:

COVID-19, Vitamin D, Inflammation

Abstract

Background: Corona virus disease (COVID-19) Was a respiratory disease. Severity of the disease was related to inflammation process. SCAP scoring system can be used to asses COVID-19 severity. Asses the severity of the disease is an important thing to determine the management. Vitamin D is shown to have anti-inflammatory effect. Vitamin D can downregulate cytokines storm and also induce innate immune activity. Here we want to know about the correlation between level of vitamin D and disease severity of COVID-19.

Methods: Cross sectional study was observed 68 patient COVID-19 in Prof. Dr. I. G. N. G Ngoerah Denpasar hospital. They were asses with SCAP scoring system dan measured their   vitamin D level at the same time. The correlation between two variable was analyze by Spearman correlation.

Results: Among those 68 Sample, the median age of the sample is 64 years old, and 52.9 % of them are male. There is correlation between level of vitamin D and severity of COVID-19, the coefficient correlation was -0.47 with p<0.001.

Conclusions: There is correlation between level of vitamin D and severity of COVID-19.

References

Diaz JV, Appiah J, Askie L, Baller A, Banerjee A, Barkley S, et al. COVID-19 clinical management: living guidance. World Health Organization: Geneva, Switzerland. 2021;81-5.

Murdaca G, Pioggia G, Negrini S. Vitamin D and Covid-19: an update on evidence and potential therapeutic implications. Clin Molecul Aller. 2020;18(1):1-8.

Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, et al. Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients. 2020;12(4):988-99.

Statsenko Y, Al Zahmi F, Habuza T, Almansoori TM, Smetanina D, Simiyu GL, et al. Impact of age and sex on COVID-19 severity assessed from radiologic and clinical findings. Front Cellular Infect Microbiol. 2022;13(1):1395-406.

Abate BB, Kassie AM, Kassaw MW, Aragie TG, Masresha SA. Sex difference in coronavirus disease (COVID-19): a systematic review and meta-analysis. BMJ Open. 2020;10(10):675-87.

Jude EB, Ling SF, Allcock R, Yeap BX, Pappachan JM. Vitamin D deficiency is associated with higher hospitalization risk from COVID-19: a retrospective case-control study. J Clin Endocrinol Metabol. 2021;106(11):708-15.

Mubina JF, Wahyuni A. Pengaruh Vitamin D terhadap Keparahan dan Mortalitas COVID-19. Med Profession J Lampung. 2021;11(1):183-9.

Dror AA, Morozov N, Daoud A, Namir Y, Yakir O, Shachar Y, et al. Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness. PLoS One. 2022;17(2):273-9.

Taboada M, Rodríguez N, Riveiro V, Abelleira R, Ricoy J, Lama A, et al. Short-term outcomes of 50 patients with acute respiratory distress by COVID-19 where prone positioning was used outside the ICU. J Clin Anesthesia. 2020;67(2):110-28.

Huang B, Wang J, Cai J, Yao S, Chan PKS, Tam TH, et al. Integrated vaccination and physical distancing interventions to prevent future COVID-19 waves in Chinese cities. Nature Human Behaviour. 2021;5(6):695-705.

Downloads

Published

2024-08-27

Issue

Section

Original Research Articles