Correlation of serum amylase level with the severity of acute organophosphorus compounds poisoning

Gunosindhu Paul; Mohammed Ruhul Kabir; A. B. M. Kamrul-Hasan; S. K. Kabir Ahammed; M. Enayet Hossain; Ferdaus Ahammed; Shishir Kumar Basak; A. F. M. Nazmul Islam

doi:10.18203/2349-3933.ijam20210591

Authors

Gunosindhu Paul Department of Medicine, Khadimpara Hospital, Sylhet, Bangladesh
Mohammed Ruhul Kabir Department of Medicine, Sylhet MAG Osmani Medical College, Sylhet, Bangladesh
A. B. M. Kamrul-Hasan Department of Endocrinology, Mymensingh Medical College, Mymensingh, Bangladesh
S. K. Kabir Ahammed Department of Medicine, Sylhet MAG Osmani Medical College, Sylhet, Bangladesh
M. Enayet Hossain Department of Medicine, Sylhet MAG Osmani Medical College, Sylhet, Bangladesh
Ferdaus Ahammed Department of Medicine, Sylhet MAG Osmani Medical College, Sylhet, Bangladesh
Shishir Kumar Basak Department of Medicine, Sylhet MAG Osmani Medical College, Sylhet, Bangladesh
A. F. M. Nazmul Islam Department of Medicine, Northeast Medical College, Sylhet, Bangladesh

DOI:

https://doi.org/10.18203/2349-3933.ijam20210591

Keywords:

Organophosphorus poisoning, Serum amylase, Peradeniya organophosphorus poisoning scale

Abstract

Background: Organophosphorus (OP) poisoning is a common mode of suicidal poisoning in our country and is associated with significant mortality and morbidity. Serum amylase has shown a promising role in the assessment of the severity of OP poisoning. We conducted this study to see the association of serum amylase level with acute OP poisoning severity.

Methods: This cross-sectional study was conducted among 150 patients admitted with acute OP poisoning to the inpatient department of medicine of a tertiary hospital in Bangladesh from July 2016 to June 2018. Peradeniya organophosphorus poisoning scale was used to detect clinical severity. Serum amylase was measured on the day of admission.

Results: The patients' mean age was 23.68±6.80 years, and 65.3% were male. As assessed by the POP scale, 56.7%, 34.7%, and 8.7% of patients had mild, moderate, and severe grades of OP poisoning, respectively. The median serum amylase level was 103.50 (IQR 73.75-156.0) IU/l; 44.7% of the subjects had normal, and 53.3% had an elevated serum amylase. A progressive increase in serum amylase level was observed with the increasing severity of OP poisoning; 77.0 IU/l (IQR 58.0-97.0) in mild grade, 154.0 IU/l (IQR 125.25-162.5) in moderate grade, and 298.0 IU/l (IQR 289.5-305.0) in severe grade and the differences in the median amylase across the three groups were statistically significant (p<0.001). A significant positive correlation between serum amylase level and POP scale score (r=0.970; p<0.001) was also observed.

Conclusions: Serum amylase level may be used as a readily available marker of the severity of acute OP poising in resource-poor settings.

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